Browsing by Author "Palmer, Brian"

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Title: 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution. Author: Palmer, Brian ; Thompson, Andrew ; Booth, RJ ; Dobrusin, EM ; Kraker, AJ ; Lee, Ho ; Lunney, EA ; Mitchell, LH ; Ortwine, DF ; Smaill, Jeffrey ; Swan, LM ; Denny, William Reference: Journal of Medicinal Chemistry 49:4896-4911 2006
Title: 6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis. Author: Tong, Amy ST ; Choi, Peter ; Blaser, Adrian ; Sutherland, Hamish ; Tsang, Sophia KY ; Guillemont, Jerome ; Motte, Magali ; Cooper, Christopher B ; Andries, Koen ; Van den Broeck, Walter ; Franzblau, Scott G ; Upton, Anna M ; Denny, William ; Palmer, Brian ; Conole, Daniel Date: (2017-10)
Title: 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases Author: Thompson, Andrew ; Blaser, Adrian ; Palmer, Brian ; Anderson, Robert ; Shinde, SS ; Launay, D ; Chatelain, E ; Maes, L ; Franzblau, SG ; Wan, B ; Wang, Y ; Ma, Z ; Denny, William Reference: Bioorganic and Medicinal Chemistry Letters 27(11):2583-2589 Jun 2017
Title: Aromatic lithiation directed by the carboxylic acid groups. Synthesis of 9-substituted dibenzodioxin-1-carboxylic acids and 6-substituted phenoxathiin-4-carboxylic acids Author: Palmer, Brian ; Boyd, Maruta ; Denny, William Reference: Journal of Organic Chemistry 55(2):438-441 1990
Title: Assays and models for in vitro and in vivo evaluation of small molecule inhibitors of tryptophan dioxygenase Author: Ching, Lai-Ming ; Tomek, Petr ; Palmer, Brian ; Tijono, S ; Henare, Kimiora ; Braun, L ; de Leeuw, Matthew Date: (2017-10-15)
Title: Biarylmethoxy 2-nitroimidazooxazine antituberculosis agents: Effects of proximal ring substitution and linker reversal on metabolism and efficacy. Author: Thompson, Andrew ; Blaser, Adrian ; Palmer, Brian ; Franzblau, Scott G ; Wan, Baojie ; Wang, Yuehong ; Ma, Zhenkun ; Denny, William Date: (2015-09)
Title: Characterization of a smart pH-cleavable PEG polymer towards the development of dual pH-sensitive liposomes. Author: Kanamala, Manju ; Palmer, Brian ; Wilson, William ; Wu, Zimei Date: (2018-09)
Title: Comparative bioactivation of the novel anti-tuberculosis agent PA-824 in Mycobacteria and a subcellular fraction of human liver Author: Dogra, M ; Palmer, Brian ; Bashiri, G ; Tingle, Malcolm ; Shinde, Sujata ; Anderson, Robert ; O'Toole, R ; Baker, Edward ; Denny, William ; Helsby, Nuala Reference: British Journal of Pharmacology 162(1):226-236 2011
Title: Development of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1) for cancer therapy: Identification of novel inhibitory fragments and modelling of binding to the active site. Author: Fung, Sai ; Flanagan, JU ; Squire, Christopher ; Palmer, Brian ; Ching, Lai-Ming Reference: New Zealand Society for Oncology Conference: Oncology in New Zealand; current and future challenges, Tauranga, Auckland, 21 Oct 2014 - 23 Oct 2014. 21 Oct 2014
Title: Development of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1) for cancer therapy: New, sensitive assay for high throughput screening of compound libraries for novel small molecule inhibitors of IDO1 Author: Tomek, Petr ; Palmer, Brian ; Flanagan, JU ; Ching, Lai-Ming Reference: New Zealand Society for Oncology Conference: Oncology in New Zealand; current and future challenges, Tauranga, New Zealand, 21 Oct 2014 - 23 Oct 2014. 21 Oct 2014
Title: Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1) Author: Fung, Sai ; Wang, H ; Tomek, Petr ; Squire, Christopher ; Flanagan, Jack ; Palmer, Brian ; Bridewell, DJA ; Tijono, Sofian ; Jamie, JF ; Ching, Lai-Ming Reference: Bioorganic and Medicinal Chemistry, 2013, 21 (24), pp. 7595 - 7603
Title: Discovery and evalution of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions Author: Tomek, Petr ; Palmer, Brian ; Flanagan, Jack ; Sun, C ; Raven, EL ; Ching, Lai-Ming Date: (2017-01-27)
Title: Dual pH-sensitive liposomes with low pH-triggered sheddable PEG for enhanced tumor-targeted drug delivery. Author: Kanamala, Manju ; Palmer, Brian ; Jamieson, Stephen ; Wilson, William R ; Wu, Zimei Reference: Nanomedicine (London, England) 14(15):1971-1989 Aug 2019
Title: Gemcitabine sensitization by Chk1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells Author: Parsels, LA ; Morgan, MA ; Tanska, DM ; Parsels, JD ; Palmer, Brian ; Booth, RJ ; Denny, William ; Canman, CE ; Kraker, AJ ; Lawrence, TS ; Maybaum, J Reference: Molecular Cancer Therapeutics 8:45-54 2009
Title: Hypoxia-selective antitumor agents .14. Synthesis and hypoxic cell cytotoxicity of regioisomers of the hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide Author: Palmer, Brian ; Wilson, William ; Anderson, Robert ; Boyd, Maruta ; Denny, William Reference: Journal of Medicinal Chemistry 39:2518-2528 1996
Title: Intermediates in the reduction of the antituberculosis drug PA-824, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine, in aqueous solution. Author: Anderson, Robert ; Shinde, Sujata ; Maroz, Andrej ; Palmer, Brian ; Boyd, Maruta ; Denny, William Reference: Organic and Biomolecular Chemistry 6:1973-1980 2008
Title: Labeling of Oxidizable Proteins with a Photoactivatable Analog of the Antitumor Agent DMXAA: Evidence for Redox Signaling in Its Mode of Action Author: Brauer, R ; Wang, L-CS ; Woon, See-Tarn ; Bridewell, David ; Henare, Kimiora ; Malinger, D ; Palmer, Brian ; Vogel, SN ; Kieda, C ; Tijono, Sofian ; Ching, Lai-Ming Reference: Neoplasia : An International Journal for Oncology Research 12(9):755-765 2010
Title: Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review. Author: Kanamala, Manju ; Wilson, William ; Yang, Mimi ; Palmer, Brian ; Wu, Zimei Date: (2016-04)
Title: The nitroimidazooxazines (PA-824 and analogs): structure-activity relationship and mechanistic studies. Author: Denny, William ; Palmer, Brian Reference: Future Medicinal Chemistry 2(8):1295-1304 Aug 2010
Title: PEG-Benzaldehyde-Hydrazone-Lipid Based PEG-Sheddable pH-Sensitive Liposomes: Abilities for Endosomal Escape and Long Circulation. Author: Kanamala, Manju ; Palmer, Brian ; Ghandehari, Hamidreza ; Wilson, William ; Wu, Zimei Date: (2018-05-31)

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