In vitro degradation and cell attachment of a PLGA coated biodegradable Mg-6Zn based alloy

Show simple item record Li, JN en Cao, Peng en Zhang, XN en Zhang, SX en He, YH en 2011-12-18T21:27:05Z en 2010 en
dc.identifier.citation Journal of Materials Science 45(22):6038-6045 2010 en
dc.identifier.issn 0022-2461 en
dc.identifier.uri en
dc.description.abstract Currently available engineering magnesium alloys have several critical concerns if they are about to be used as biomaterials, particularly the concern about the toxicity of the common alloying elements such as aluminum and rare earth (RE). There is an increasing demand to develop new magnesium alloys that do not contain any toxic elements. It is also desirable, yet challenging, to develop such a material that has a controllable degradation rate in the human fluid environment. This paper presents mechanical properties, degradation, and in vitro cell attachment of a newly developed Mg–6Zn magnesium alloy. The alloy demonstrated comparable mechanical properties with typical engineering magnesium alloys. However, the bare alloy did not show an acceptable corrosion (degradation) rate. Application of a polymeric PLGA or poly(lactide-co-glycolide) coating significantly decreased the degradation rate. The results obtained from cell attachment experiments indicated that the mouse osteoblast-like MC3T3 cells could develop enhanced confluence on and interactions with the coated samples. en
dc.publisher Springer Verlag (Germany) en
dc.relation.ispartofseries Journal of Materials Science en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title In vitro degradation and cell attachment of a PLGA coated biodegradable Mg-6Zn based alloy en
dc.type Journal Article en
dc.identifier.doi 10.1007/s10853-010-4688-9 en
pubs.issue 22 en
pubs.begin-page 6038 en
pubs.volume 45 en
dc.rights.holder Copyright: Springer Verlag (Germany) en
pubs.end-page 6045 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 159758 en Engineering en Chemical and Materials Eng en
dc.identifier.eissn 1573-4803 en
pubs.record-created-at-source-date 2011-12-19 en

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