MHC haplotypes and response to immunocontraceptive vaccines in the Brushtail possum.

Show simple item record Holland, Olivia en Cowan, PE en Gleeson, DM en Duckworth, JA en Chamley, Lawrence en 2011-12-19T23:54:28Z en 2009 en
dc.identifier.citation Journal of Reproductive Immunology 82(1):57-65 2009 en
dc.identifier.issn 0165-0378 en
dc.identifier.uri en
dc.description.abstract The possum is a major invasive pest in New Zealand. One option for its control is the use of immunocontraceptive vaccines. Initial trials of vaccines have shown individual variation in response. The use of vaccines on wild populations could result in the evolution of a resistant population through selection for possums that remain fertile because of low or no response. Understanding the basis of this variation is therefore important. The major histocompatibility complex (MHC) is an important influence on the nature of immune responses. This study has investigated the relationship between MHC alleles and individual immune responses to immunocontraceptive vaccines comprising zona pellucida peptides. We identified MHC alleles and putative haplotypes, and compared these between individuals with measured responses to immunocontraceptive vaccines. Two haplotypes were found to associate significantly with differences in vaccine response. Possums that carried haplotype 6 showed reduced responsiveness to one vaccine, while possums that carried haplotype 9 showed increased responsiveness to a separate vaccine. The identification of MHC haplotypes associated with different responses to immunocontraceptive vaccines offers the opportunity to understand what factors trigger non-response and the persistence of fertility in some individuals, and may allow vaccines to be optimised to minimise non-responsiveness. en
dc.publisher Elsevier Ireland Ltd. en
dc.relation.ispartofseries Journal of Reproductive Immunology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title MHC haplotypes and response to immunocontraceptive vaccines in the Brushtail possum. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.jri.2009.04.008 en
pubs.issue 1 en
pubs.begin-page 57 en
pubs.volume 82 en
dc.rights.holder Copyright: Elsevier Ireland Ltd. en
dc.identifier.pmid 19577310 en
pubs.end-page 65 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 97986 en Medical and Health Sciences en School of Medicine en Obstetrics and Gynaecology en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 19577310 en

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