The effects of nociceptin/orphanin FQ receptor agonist Ro 64-6198 and diazepam on antinociception and remifentanil self-administration in rhesus monkeys.

The effects of nociceptin/orphanin FQ receptor agonist Ro 64-6198 and diazepam on antinociception and remifentanil self-administration in rhesus monkeys.

Podlesnik, Christopher ; Ko, MC ; Winger, G ; Wichmann, J ; Prinssen, EP ; Woods, JH
Identifier: http://hdl.handle.net/2292/10216
Issue Date: 2011-01
Reference: Psychopharmacology 213(1):53-60 Jan 2011
Rights: Copyright: Springer Verlag (Germany)
Rights (URI): https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm

Abstract:

The synthetic nonpeptide NOP (nociceptin/orphanin FQ peptide) receptor agonist Ro 64-6198 produces antinociception in rhesus monkeys. In rodents, it has much more variable effects on pain responses, but has response rate-increasing effects on punished operant behavior and decreases drug reward.

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DOI: 10.1007/s00213-010-2012-7
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