dc.contributor.author |
Podlesnik, Christopher |
en |
dc.contributor.author |
Jimenez-Gomez, C |
en |
dc.contributor.author |
Shahan, TA |
en |
dc.coverage.spatial |
England |
en |
dc.date.accessioned |
2011-12-20T01:50:03Z |
en |
dc.date.issued |
2006-06 |
en |
dc.identifier.citation |
Behavioural Pharmacology 17(4):369-374 Jun 2006 |
en |
dc.identifier.issn |
0955-8810 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/10230 |
en |
dc.description.abstract |
Findings from basic behavioral research suggest that simply discontinuing reinforcement for a recently reinforced operant response can cause the recurrence (i.e. resurgence) of a different previously reinforced response. The present experiment examined resurgence as an animal model of drug relapse. Initially, rats pressed levers to self-administer alcohol during baseline conditions. Next, alcohol self-administration was discontinued and non-drug reinforcers (food pellets) were presented contingent on an alternative response (chain pulling). Finally, when the non-drug reinforcer was discontinued, alcohol seeking recurred even though alcohol was still unavailable for lever pressing. These results suggest that simply discontinuing non-drug reinforcement for a behavior may be sufficient to produce relapse to drug seeking. The resurgence procedure could provide a method to examine environmental, pharmacological, and neurobiological factors that lead to relapse following the loss of a non-drug source of reinforcement. |
en |
dc.language |
eng |
en |
dc.publisher |
lippincott williams and wilkins |
en |
dc.relation.ispartofseries |
Behavioural Pharmacology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0955-8810/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Alcoholism |
en |
dc.subject |
Animals |
en |
dc.subject |
Conditioning, Operant |
en |
dc.subject |
Disease Models, Animal |
en |
dc.subject |
Extinction, Psychological |
en |
dc.subject |
Food |
en |
dc.subject |
Male |
en |
dc.subject |
Rats |
en |
dc.subject |
Rats, Long-Evans |
en |
dc.subject |
Recurrence |
en |
dc.subject |
Reinforcement (Psychology) |
en |
dc.title |
Resurgence of alcohol seeking produced by discontinuing non-drug reinforcement as an animal model of drug relapse. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1097/01.fbp.0000224385.09486.ba |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
369 |
en |
pubs.volume |
17 |
en |
dc.rights.holder |
Copyright: 2006 Lippincott Williams & Wilkins, Inc. |
en |
dc.identifier.pmid |
16914956 |
en |
pubs.end-page |
374 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
208597 |
en |
dc.identifier.pii |
00008877-200606000-00010 |
en |
pubs.record-created-at-source-date |
2011-12-20 |
en |
pubs.dimensions-id |
16914956 |
en |