Abstract:
Since the late 1970s antisense oligonucleotides (AsONs) have been investigated as powerful tools for selective regulation of gene expression. Antisense drugs act by specifically binding to the target mRNA, which results in inhibition of their translation into a protein. They have already been proven efficient for the treatment of various viral infections, such as human immunodeficiency virus (HIV) type 1, hepatitis B virus, and human cytomegalovirus (CMV), and are also believed to be valuable candidates for cancer treatment. ...
