dc.contributor.author |
Gusso, Silmara |
en |
dc.contributor.author |
Hofman, Paul |
en |
dc.contributor.author |
Lalande, S |
en |
dc.contributor.author |
Cutfield, Wayne |
en |
dc.contributor.author |
Robinson, Elizabeth |
en |
dc.contributor.author |
Baldi, James |
en |
dc.date.accessioned |
2012-01-12T00:08:51Z |
en |
dc.date.issued |
2008 |
en |
dc.identifier.citation |
Diabetologia 51(7):1317-1320 2008 |
en |
dc.identifier.issn |
0012-186X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/10476 |
en |
dc.description.abstract |
Aim/hypothesis This study was designed to determine whether type 2 diabetic adolescents have reduced aerobic capacity and to investigate the role of cardiac output and arteriovenous oxygen difference (a−vO2) in their exercise response. Methods Female adolescents (age 12–18 years) with type 2 diabetes mellitus (n = 8) and type 1 diabetes mellitus (n = 12) and obese (n = 10) and non-obese (n = 10) non-diabetic controls were recruited for this study. Baseline data included maximal aerobic capacity (cycle ergometer) and body composition. Cardiac output and a−vO2 were determined at rest and during submaximal exercise. Results Diabetic groups had lower aerobic capacity than non-diabetic groups (p < 0.05). Adolescents with type 2 diabetes had lower aerobic capacity than the type 1 diabetic group. Maximal heart rate was lower in the type 2 diabetic group (p < 0.05). Exercise stroke volume was 30–40% lower at 100 and 120 beats per min in the diabetic than in the non-diabetic groups (p < 0.05). The a−vO2 value was not different in any condition. Conclusions and interpretation Type 2 diabetic adolescents have reduced aerobic capacity and reduced heart rate response to maximal exercise. Furthermore, type 2 and type 1 diabetic adolescent girls have a blunted exercise stroke volume response compared with non-diabetic controls. Central rather than peripheral mechanisms contribute to the reduced aerobic capacity in diabetic adolescents. Although of short duration, type 2 diabetes in adolescence is already affecting cardiovascular function in adolescents. |
en |
dc.publisher |
Springer Verlag |
en |
dc.relation.ispartofseries |
Diabetologia |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0012-186X/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Impaired stroke volume and aerobic capacity in female adolescents with type 1 and type 2 diabetes mellitus |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1007/s00125-008-1012-1 |
en |
pubs.issue |
7 |
en |
pubs.begin-page |
1317 |
en |
pubs.volume |
51 |
en |
dc.rights.holder |
Copyright: Springer Verlag |
en |
dc.identifier.pmid |
18446317 |
en |
pubs.end-page |
1320 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
83901 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Exercise Sciences |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
18446317 |
en |