dc.contributor.author |
Lalande, S |
en |
dc.contributor.author |
Gusso, Silmara |
en |
dc.contributor.author |
Hofman, Paul |
en |
dc.contributor.author |
Baldi, JC |
en |
dc.date.accessioned |
2012-01-12T00:09:17Z |
en |
dc.date.issued |
2008 |
en |
dc.identifier.citation |
Medicine and Science in Sports and Exercise 40(4):612-617 2008 |
en |
dc.identifier.issn |
0195-9131 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/10477 |
en |
dc.description.abstract |
It is unclear whether impaired cardiac and/or vascular function contribute to exercise intolerance in patients with type 2 diabetes. Purpose: Magnetic resonance imaging (MRI) was used to determine whether reductions in cardiac output and/or femoral arterial blood flow contribute to reduced aerobic capacity in patients with type 2 diabetes. Methods: Cardiac and femoral arterial blood flow MRI scans were performed at rest and during low-intensity leg exercise in eight patients with type 2 diabetes and 11 healthy individuals. Maximal aerobic capacity (V·O2max) and maximal oxygen pulse were also determined in all participants. Results: V·O2max was 20% lower and maximal oxygen pulse was 16% lower in patients with type 2 diabetes (P < 0.05), whereas maximal heart rate was the same between groups. Low-intensity exercise induced a 20% increase in heart rate and cardiac output as well as a 60-70% increase in femoral blood flow in both groups (P < 0.05). Femoral arterial blood flow indexed to thigh lean mass was reduced during exercise in patients with type 2 diabetes compared with healthy individuals. Stroke volume indexed to fat-free mass was lower in patients with type 2 diabetes, but greater heart rate allowed cardiac output to be maintained during submaximal exercise. Conclusions: These findings suggest that impaired femoral arterial blood flow, an indirect marker of muscle perfusion, affects low-intensity exercise performance in patients with type 2 diabetes. However, because of lower exercising stroke volume, we propose that femoral arterial blood flow and, possibly, cardiac output, limit V·O2max in patients with type 2 diabetes. |
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dc.publisher |
American College of Sports Medicine (acsm) |
en |
dc.relation.ispartofseries |
Medicine and Science in Sports and Exercise |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0195-9131/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Reduced Leg Blood Flow during Submaximal Exercise in Type 2 Diabetes |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1249/MSS.0b013e318161aa99 |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
612 |
en |
pubs.volume |
40 |
en |
dc.rights.holder |
Copyright: 2008 the American College of Sports Medicine |
en |
dc.identifier.pmid |
18317387 |
en |
pubs.end-page |
617 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
78265 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Exercise Sciences |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
18317387 |
en |