Bayesian coalescent inference of major human mitochondrial DNA haplogroup expansions in Africa

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dc.contributor.author Atkinson, Quentin en
dc.contributor.author Gray, Russell en
dc.contributor.author Drummond, Alexei en
dc.date.accessioned 2012-01-23T02:00:56Z en
dc.date.issued 2009 en
dc.identifier.citation Proceedings of the Royal Society of London Series B-Biological Sciences 276(1655):367-373 2009 en
dc.identifier.issn 0080-4649 en
dc.identifier.uri http://hdl.handle.net/2292/10652 en
dc.description.abstract Past population size can be estimated from modern genetic diversity using coalescent theory. Estimates of ancestral human population dynamics in sub-Saharan Africa can tell us about the timing and nature of our first steps towards colonizing the globe. Here, we combine Bayesian coalescent inference with a dataset of 224 complete human mitochondrial DNA (mtDNA) sequences to estimate effective population size through time for each of the four major African mtDNA haplogroups (L0–L3). We find evidence of three distinct demographic histories underlying the four haplogroups. Haplogroups L0 and L1 both show slow, steady exponential growth from 156 to 213 kyr ago. By contrast, haplogroups L2 and L3 show evidence of substantial growth beginning 12–20 and 61–86 kyr ago, respectively. These later expansions may be associated with contemporaneous environmental and/or cultural changes. The timing of the L3 expansion—8–12 kyr prior to the emergence of the first non-African mtDNA lineages—together with high L3 diversity in eastern Africa, strongly supports the proposal that the human exodus from Africa and subsequent colonization of the globe was prefaced by a major expansion within Africa, perhaps driven by some form of cultural innovation. en
dc.publisher The Royal Society en
dc.relation.ispartofseries Proceedings of the Royal Society of London Series B - Biological Sciences en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Bayesian coalescent inference of major human mitochondrial DNA haplogroup expansions in Africa en
dc.type Journal Article en
dc.identifier.doi 10.1098/rspb.2008.0785 en
pubs.issue 1655 en
pubs.begin-page 367 en
pubs.volume 276 en
dc.rights.holder Copyright: 2008 The Royal Society en
dc.identifier.pmid 18826938 en
pubs.end-page 373 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 96381 en
pubs.org-id Science en
pubs.org-id Biological Sciences en
pubs.org-id Psychology en
dc.identifier.eissn 1471-2954 en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 18826938 en


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