SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway.

Show simple item record Jeyifous, O en Waites, CL en Specht, C en Fujisawa, S en Schubert, M en Lin, E en Marshall, J en Aoki, C en de Silva, T en Montgomery, Johanna en Garner, Craig en Green, WN en 2012-02-02T01:21:01Z en 2009 en
dc.identifier.citation Nature Neuroscience 12(8):1011-1109 2009 en
dc.identifier.issn 1097-6256 en
dc.identifier.uri en
dc.description.abstract Synaptic plasticity is dependent on the differential sorting, delivery and retention of neurotransmitter receptors, but the mechanisms underlying these processes are poorly understood. We found that differential sorting of glutamate receptor subtypes began in the endoplasmic reticulum of rat hippocampal neurons. As AMPA receptors (AMPARs) were trafficked to the plasma membrane via the conventional somatic Golgi network, NMDA receptors (NMDARs) were diverted from the somatic endoplasmic reticulum into a specialized endoplasmic reticulum subcompartment that bypasses somatic Golgi, merging instead with dendritic Golgi outposts. This endoplasmic reticulum subcompartment was composed of highly mobile vesicles containing the NMDAR subunits NR1 and NR2B, the microtubule-dependent motor protein KIF17, and the postsynaptic adaptor proteins CASK and SAP97. Our data demonstrate that the retention and trafficking of NMDARs in this endoplasmic reticulum subcompartment requires both CASK and SAP97. These findings indicate that NMDARs are sorted away from AMPARs via a non-conventional secretory pathway that utilizes dendritic Golgi outposts. en
dc.publisher Nature Publishing Group en
dc.relation.ispartofseries Nature Neuroscience en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtains from en
dc.rights.uri en
dc.title SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway. en
dc.type Journal Article en
dc.identifier.doi 10.1038/nn.2362 en
pubs.issue 8 en
pubs.begin-page 1011 en
pubs.volume 12 en
dc.rights.holder Copyright: 2009 Nature America, Inc en
pubs.end-page 1109 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 89698 en Medical and Health Sciences en Medical Sciences en Physiology Division en
pubs.record-created-at-source-date 2010-09-01 en

Files in this item

There are no files associated with this item.

Find Full text

This item appears in the following Collection(s)

Show simple item record


Search ResearchSpace