dc.contributor.author |
Cheyne, Juliette |
en |
dc.contributor.author |
Montgomery, Johanna |
en |
dc.date.accessioned |
2012-02-02T01:37:50Z |
en |
dc.date.issued |
2008 |
en |
dc.identifier.citation |
Molecular and Cellular Neuroscience 37(3):432-439 2008 |
en |
dc.identifier.issn |
1044-7431 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/10863 |
en |
dc.description.abstract |
Group I metabotropic glutamate receptors, mGluR1 and mGluR5, modulate NMDA receptor-mediated synaptic transmission and plasticity and mediate mGluR-dependent plasticity. Here we report that the synaptic expression of mGluRs can be regulated by NMDA receptor-dependent synaptic plasticity, but that this is dependent on the subtype of mGluR. Silent synapses, but not active synapses, were found to lack Group I mGluRs showing that mGluRs must be inserted into synapses after they are unsilenced. The induction of LTP resulted in an increased synaptic expression of mGluR1 in an NMDA receptor-dependent manner. mGluR1 is internalized from synapses via NMDA receptor-dependent LTD. Interestingly we found no evidence for the regulation of mGluR5 by NMDA receptor-dependent plasticity. This regulation of Group I mGluRs will determine the ability of synapses to undergo mGluR-dependent modulation of synaptic transmission and plasticity, providing a mechanism for metaplasticity and state-dependent plasticity at hippocampal synapses. |
en |
dc.publisher |
Elsevier Inc. |
en |
dc.relation.ispartofseries |
Molecular and Cellular Neuroscience |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1044-7431/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Plasticity-dependent changes in metabotropic glutamate receptor expression at excitatory hippocampal synapses |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.mcn.2007.10.015 |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
432 |
en |
pubs.volume |
37 |
en |
dc.rights.holder |
Copyright: Elsevier Inc. |
en |
dc.identifier.pmid |
18191411 |
en |
pubs.end-page |
439 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
79483 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Physiology Division |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
18191411 |
en |