A Role for Human Neuroglobin in Apoptosis

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dc.contributor.author Brittain, Tom en
dc.contributor.author Skommer, J en
dc.contributor.author Henty, Kristen en
dc.contributor.author Birch, Nigel en
dc.contributor.author Raychaudhuri, S en
dc.date.accessioned 2011-09-07T01:21:51Z en
dc.date.accessioned 2012-02-09T22:14:05Z en
dc.date.issued 2010-12 en
dc.identifier.citation IUBMB Life 62(12):878-885 Dec 2010 en
dc.identifier.issn 1521-6543 en
dc.identifier.uri http://hdl.handle.net/2292/11065 en
dc.description.abstract Over the past decade, following the discovery of the human heme protein neuroglobin, many studies have searched for evidence for this protein's mechanism of action. Much data has accrued showing that high levels of neuroglobin will protect cells from apoptotic cell death, following a wide range of challenges. Various explanations of its actions, based on measured reactivity with oxygen, nitric oxide, or free radicals, have been proposed, but none have, as yet, been substantiated in vivo. Following preliminary experiments, it was previously hypothesised that "the central role of neuroglobin in highly metabolically active cells and retinal and brain neurons is to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis" (I.U.M.B.M. Life (2008) 60, 398). In this article, we review the evidence, which has accumulated to support this hypothesised mechanism of action of neuroglobin and integrate this data, with other reported intracellular functions of neuroglobin, to suggest a plausible central role for neuroglobin in the control of apoptosis. en
dc.publisher Wiley-Blackwell en
dc.relation.ispartofseries IUBMB Life en
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dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1521-6543/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title A Role for Human Neuroglobin in Apoptosis en
dc.type Journal Article en
dc.identifier.doi 10.1002/iub.405 en
pubs.issue 12 en
pubs.begin-page 875 en
pubs.volume 62 en
dc.rights.holder Copyright: International Union of Biochemistry and Molecular Biology (IUBMB); Wiley-Blackwell en
dc.identifier.pmid 21190290 en
pubs.author-url http://onlinelibrary.wiley.com/doi/10.1002/iub.405/pdf en
pubs.end-page 885 en
pubs.merge-from 2292/18909 en
pubs.merge-from http://hdl.handle.net/2292/18909 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 159397 en
dc.identifier.eissn 1521-6551 en
pubs.record-created-at-source-date 2011-09-16 en
pubs.dimensions-id 21190290 en


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