A Multiscale Model of the Electrophysiological Basis of the Human Electrogastrogram

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dc.contributor.author Pullan, Andrew en
dc.contributor.author O'Grady, Gregory en
dc.contributor.author Du, Peng en
dc.contributor.author Cheng, Leo en
dc.date.accessioned 2012-02-10T02:14:44Z en
dc.date.issued 2010 en
dc.identifier.citation Biophys J 99(9):2784-2792 03 Nov 201 en
dc.identifier.issn 0006-3495 en
dc.identifier.uri http://hdl.handle.net/2292/11125 en
dc.description.abstract The motility of the stomach is coordinated by an electrical activity termed “slow waves”, and slow-wave dysrhythmias contribute to motility disorders. One major method for clinically evaluating gastric dysrhythmias has been electrogastrography (EGG); however, the clinical utility of EGG is limited partly due to the uncertainty regarding its electrophysiological basis. In this study, a multiscale model of gastric slow waves was generated from a biophysically based continuum description of cellular electrical events, coupled with a subject-specific human stomach model and high-resolution electrical mapping data. The model was then applied using a forward-modeling approach, within an anatomical torso model, to define how slow wave activity summates to generate the EGG potentials. The simulated EGG potentials were shown to be spatially varying in amplitude (0.27–0.33 mV) and duration (9.2–15.3 s), and the sources of this variance were quantified with respect to the activation timings of the underlying slow wave activity. This model constitutes an improved theory of the electrophysiological basis of the EGG, and offers a framework for optimizing the placement of EGG electrodes, and for interpreting the EGG changes occurring in disease states. en
dc.publisher the Biophysical Society en
dc.relation.ispartofseries Biophysical Journal en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0006-3495/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title A Multiscale Model of the Electrophysiological Basis of the Human Electrogastrogram en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.bpj.2010.08.067 en
pubs.issue 9 en
pubs.begin-page 2784 en
pubs.volume 99 en
dc.rights.holder Copyright: The Biophysical Society en
dc.identifier.pmid 21044575 en
pubs.end-page 2792 en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 181877 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
pubs.org-id Engineering en
pubs.org-id Engineering Science en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Surgery Department en
pubs.record-created-at-source-date 2010-11-23 en
pubs.dimensions-id 21044575 en


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