Three-dimensional transmural organization of perimysial collagen in the heart

Show simple item record Pope, Adele en Sands, Gregory en Smaill, Bruce en Le Grice, Ian en 2012-02-13T03:04:33Z en 2008 en
dc.identifier.citation American Journal of Physiology-Heart and Circulatory Physiology 295(3):H1243-H1252 2008 en
dc.identifier.issn 0363-6135 en
dc.identifier.uri en
dc.description.abstract There is strong support for the view that the ventricular myocardium has a laminar organization in which myocytes are grouped into branching layers separated by cleavage planes. However, understanding of the extent and functional implications of this architecture has been limited by the lack of a systematic three-dimensional description of the organization of myocytes and associated perimysial collagen. We imaged myocytes and collagen across the left ventricular wall at high resolution in seven normal rat hearts using extended volume confocal microscopy. We developed novel reconstruction and segmentation techniques necessary for the quantitative analysis of three-dimensional myocyte and perimysial collagen organization. The results confirm that perimysial collagen has an ordered arrangement and that it defines a laminar organization. Perimysial collagen is composed of three distinct forms: extensive meshwork on laminar surfaces, convoluted fibers connecting adjacent layers, and longitudinal cords. While myolaminae are the principal form of structural organization throughout most of the wall, they are not seen in the subepicardium, where perimysial collagen is present only as longitudinal cords. en
dc.publisher the American Physiological Society en
dc.relation.ispartofseries American Journal of Physiology - Heart and Circulatory Physiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Three-dimensional transmural organization of perimysial collagen in the heart en
dc.type Journal Article en
dc.identifier.doi 10.1152/ajpheart.00484.2008 en
pubs.issue 3 en
pubs.begin-page H1243 en
pubs.volume 295 en
dc.rights.holder Copyright: the American Physiological Society en
dc.identifier.pmid 18641274 en
pubs.end-page H1252 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 78494 en Bioengineering Institute en ABI Associates en Medical and Health Sciences en Medical Sciences en Physiology Division en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 18641274 en

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