Is type 2 diabetes an amyloidosis and does it really matter (to patients)?

Cooper, Garth; Aitken, Jacqueline; Zhang, Shaoping

dc.contributor.author	Cooper, Garth	en
dc.contributor.author	Aitken, Jacqueline	en
dc.contributor.author	Zhang, Shaoping	en
dc.date.accessioned	2012-02-23T00:07:07Z	en
dc.date.issued	2010-06	en
dc.identifier.citation	DIABETOLOGIA 53(6):1011-1016 Jun 2010	en
dc.identifier.issn	0012-186X	en
dc.identifier.uri	http://hdl.handle.net/2292/11662	en
dc.description.abstract	Degeneration of pancreatic islet beta cells is increasingly ranked as a key disease mechanism in type 2 diabetes, but it is not entirely clear what the underlying molecular processes might be and how they attack insulin production, ultimately causing type 2 diabetes [3, 4]. However, recent studies based on quantitative measurements in post mortem pancreatic tissue from humans with type 2 diabetes have reinforced earlier observations concerning the probable role of lowered beta cell numbers and pointed to a linkage between beta cell disappearance and beta cell apoptosis.	en
dc.language	EN	en
dc.publisher	SPRINGER	en
dc.relation.ispartofseries	Diabetologia	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0012-186X/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	ISLET BETA-CELLS	en
dc.subject	GENE-RELATED PEPTIDE	en
dc.subject	HUMAN AMYLIN	en
dc.subject	TRANSGENIC MICE	en
dc.subject	FIBRIL FORMATION	en
dc.subject	POLYPEPTIDE	en
dc.subject	APOPTOSIS	en
dc.subject	MELLITUS	en
dc.subject	PROTEIN	en
dc.subject	LANGERHANS	en
dc.title	Is type 2 diabetes an amyloidosis and does it really matter (to patients)?	en
dc.type	Journal Article	en
dc.identifier.doi	10.1007/s00125-010-1715-y	en
pubs.issue	6	en
pubs.begin-page	1011	en
pubs.volume	53	en
dc.rights.holder	Copyright: SPRINGER	en
dc.identifier.pmid	20229094	en
pubs.end-page	1016	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	119333	en
pubs.org-id	Science	en
pubs.org-id	Biological Sciences	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
pubs.record-created-at-source-date	2012-02-15	en
pubs.dimensions-id	20229094	en