Solution conformation of a tetradecapeptide stabilized by two di-n-propyl glycine residues

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dc.contributor.author Sarojini Amma, Vijayalekshmi en
dc.contributor.author Rao, RB en
dc.contributor.author Ragothama, S en
dc.contributor.author Balaram, P en
dc.date.accessioned 2012-02-23T00:20:30Z en
dc.date.issued 2010 en
dc.identifier.citation Journal of Peptide Science 16(8):430-436 Aug 2010 en
dc.identifier.issn 1075-2617 en
dc.identifier.uri http://hdl.handle.net/2292/11684 en
dc.description.abstract The solution conformation of a designed tetradecapeptide Boc-Val-Ala-Leu-Dpg-Val-Ala-Leu-Val-Ala-Leu-Dpg-Val-Ala-Leu-OMe (Dpg-14) containing two di-n-propyl glycine (Dpg) residues has been investigated by ^1H NMR and circular dichroism in organic solvents. The peptide aggregates formed at a concentration of 3 mM in the apolar solvent CDCl3 were broken by the addition of 12% v/v of the more polar solvent DMSO-d6. Successive NiH Ni+1H NOEs observed over the entire length of the sequence in this solvent mixture together with the observation of several characteristic medium-range NOEs support a major population of continuous helical conformations for Dpg-14. Majority of the observed coupling constants (3JNHCαH) also support φ values in the helical conformation. Circular dichroism spectra recorded in methanol and propan-2-ol give further support in favor of helical conformation for Dpg-14 and the stability of the helix at higher temperature. en
dc.publisher John Wiley & Sons Ltd. en
dc.relation.ispartofseries Journal of Peptide Science en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: http://www.sherpa.ac.uk/romeo/issn/1075-2617/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Solution conformation of a tetradecapeptide stabilized by two di-n-propyl glycine residues en
dc.type Journal Article en
dc.identifier.doi 10.1002/psc.1259 en
pubs.begin-page 430 en
pubs.volume 16 en
dc.rights.holder Copyright: John Wiley & Sons Ltd. en
dc.identifier.pmid 20623490 en
pubs.end-page 436 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 102704 en
pubs.org-id Science en
pubs.org-id Chemistry en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 20623490 en


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