Effect of Dual-Focus soft contact lens wear on axial myopia progression in children

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dc.contributor.author Anstice, Nicola en
dc.contributor.author Phillips, John en
dc.date.accessioned 2012-02-23T01:21:32Z en
dc.date.issued 2011 en
dc.identifier.citation Ophthalmology 118(6):1152-1161 Jun 2011 en
dc.identifier.issn 0161-6420 en
dc.identifier.uri http://hdl.handle.net/2292/11773 en
dc.description.abstract Purpose: To test the efficacy of an experimental Dual-Focus (DF) soft contact lens in reducing myopia progression. Design: Prospective, randomized, paired-eye control, investigator-masked trial with cross-over. Participants: Forty children, 11–14 years old, with mean spherical equivalent refraction (SER) of 2.71 1.10 diopters (D). Methods: Dual-Focus lenses had a central zone that corrected refractive error and concentric treatment zones that created 2.00 D of simultaneous myopic retinal defocus during distance and near viewing. Control was a single vision distance (SVD) lens with the same parameters but without treatment zones. Children wore a DF lens in 1 randomly assigned eye and an SVD lens in the fellow eye for 10 months (period 1). Lens assignment was then swapped between eyes, and lenses were worn for a further 10 months (period 2). Main Outcome Measures: Primary outcome was change in SER measured by cycloplegic autorefraction over 10 months. Secondary outcome was a change in axial eye length (AXL) measured by partial coherence interferometry over 10 months. Accommodation wearing DF lenses was assessed using an open-field autorefractor. Results: In period 1, the mean change in SER with DF lenses ( 0.44 0.33 D) was less than with SVD lenses ( 0.69 0.38 D; P 0.001); mean increase in AXL was also less with DF lenses (0.11 0.09 mm) than with SVD lenses (0.22 0.10 mm; P 0.001). In 70% of the children, myopia progression was reduced by 30% or more in the eye wearing the DF lens relative to that wearing the SVD lens. Similar reductions in myopia progression and axial eye elongation were also observed with DF lens wear during period 2. Visual acuity and contrast sensitivity with DF lenses were not significantly different than with SVD lenses. Accommodation to a target at 40 cm was driven through the central distance-correction zone of the DF lens. Conclusions: Dual-Focus lenses provided normal acuity and contrast sensitivity and allowed accommodation to near targets. Myopia progression and eye elongation were reduced significantly in eyes wearing DF lenses. The data suggest that sustained myopic defocus, even when presented to the retina simultaneously with a clear image, can act to slow myopia progression without compromising visual function. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references. en
dc.publisher 2011 by the American Academy of Ophthalmology and Elsevier Inc. en
dc.relation.ispartofseries Ophthalmology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0161-6420/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Effect of Dual-Focus soft contact lens wear on axial myopia progression in children en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.ophtha.2010.10.035, en
pubs.issue 6 en
pubs.begin-page 1152 en
pubs.volume 118 en
dc.rights.holder Copyright: 2011 by the American Academy of Ophthalmology and Elsevier Inc. en
dc.identifier.pmid 21276616 en
pubs.end-page 1161 en
pubs.publication-status Accepted en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 243247 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Optometry and Vision Science en
pubs.record-created-at-source-date 2010-11-19 en
pubs.dimensions-id 21276616 en

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