Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifen-resistant breast cancer cells.

Leung, Yee Fun; Kim, Ji Eun; Rewcastle, Gordon; Finlay, Graeme; Baguley, Bruce

dc.contributor.author	Leung, Yee Fun	en
dc.contributor.author	Kim, Ji Eun	en
dc.contributor.author	Rewcastle, Gordon	en
dc.contributor.author	Finlay, Graeme	en
dc.contributor.author	Baguley, Bruce	en
dc.coverage.spatial	United States	en
dc.date.accessioned	2012-02-26T19:19:58Z	en
dc.date.issued	2011-06-01	en
dc.identifier.citation	Cancer Biology & Therapy 11(11):938-946 01 Jun 2011	en
dc.identifier.uri	http://hdl.handle.net/2292/11960	en
dc.description.abstract	Treatment with anti-estrogens or aromatase inhibitors is commonly used for patients with estrogen receptor-positive (ER+) breast cancers; however resistant disease develops almost inevitably, requiring a choice of secondary therapy. One possibility is to use inhibitors of the PI3K/mTOR pathway and several candidate drugs are in development. We examined the in vitro effects of two inhibitors of the PI3K/mTOR pathway on resistant MCF-7 cells.	en
dc.language	eng	en
dc.publisher	Landes Bioscience	en
dc.relation.ispartofseries	Cancer Biology & Therapy	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: http://www.sherpa.ac.uk/romeo/issn/1538-4047/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	Antineoplastic Agents, Hormonal	en
dc.subject	Breast Neoplasms	en
dc.subject	Cell Line, Tumor	en
dc.subject	Cell Proliferation	en
dc.subject	Drug Resistance, Neoplasm	en
dc.subject	Extracellular Signal-Regulated MAP Kinases	en
dc.subject	Female	en
dc.subject	G1 Phase	en
dc.subject	Humans	en
dc.subject	Imidazoles	en
dc.subject	Neoplasms, Hormone-Dependent	en
dc.subject	Phosphatidylinositol 3-Kinases	en
dc.subject	Phosphorylation	en
dc.subject	Poly(ADP-ribose) Polymerases	en
dc.subject	Proto-Oncogene Proteins c-akt	en
dc.subject	Quinolines	en
dc.subject	Receptors, Estrogen	en
dc.subject	Ribosomal Protein S6	en
dc.subject	Sulfonamides	en
dc.subject	TOR Serine-Threonine Kinases	en
dc.subject	Tamoxifen	en
dc.title	Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifen-resistant breast cancer cells.	en
dc.type	Journal Article	en
dc.identifier.doi	10.4161/cbt.11.11.15527	en
pubs.issue	11	en
pubs.begin-page	938	en
pubs.volume	11	en
dc.rights.holder	Copyright: Landes Bioscience	en
dc.identifier.pmid	21464613	en
pubs.end-page	946	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	208954	en
pubs.org-id	Medical and Health Sciences	en
pubs.org-id	Medical Sciences	en
pubs.org-id	Auckland Cancer Research	en
pubs.org-id	Molecular Medicine	en
pubs.org-id	Science	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
dc.identifier.eissn	1555-8576	en
dc.identifier.pii	15527	en
pubs.record-created-at-source-date	2012-03-03	en
pubs.dimensions-id	21464613	en