Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifen-resistant breast cancer cells.

Show simple item record Leung, Yee Fun en Kim, Ji Eun en Rewcastle, Gordon en Finlay, Graeme en Baguley, Bruce en
dc.coverage.spatial United States en 2012-02-26T19:19:58Z en 2011-06-01 en
dc.identifier.citation Cancer Biology & Therapy 11(11):938-946 01 Jun 2011 en
dc.identifier.uri en
dc.description.abstract Treatment with anti-estrogens or aromatase inhibitors is commonly used for patients with estrogen receptor-positive (ER+) breast cancers; however resistant disease develops almost inevitably, requiring a choice of secondary therapy. One possibility is to use inhibitors of the PI3K/mTOR pathway and several candidate drugs are in development. We examined the in vitro effects of two inhibitors of the PI3K/mTOR pathway on resistant MCF-7 cells. en
dc.language eng en
dc.publisher Landes Bioscience en
dc.relation.ispartofseries Cancer Biology & Therapy en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: en
dc.rights.uri en
dc.subject Antineoplastic Agents, Hormonal en
dc.subject Breast Neoplasms en
dc.subject Cell Line, Tumor en
dc.subject Cell Proliferation en
dc.subject Drug Resistance, Neoplasm en
dc.subject Extracellular Signal-Regulated MAP Kinases en
dc.subject Female en
dc.subject G1 Phase en
dc.subject Humans en
dc.subject Imidazoles en
dc.subject Neoplasms, Hormone-Dependent en
dc.subject Phosphatidylinositol 3-Kinases en
dc.subject Phosphorylation en
dc.subject Poly(ADP-ribose) Polymerases en
dc.subject Proto-Oncogene Proteins c-akt en
dc.subject Quinolines en
dc.subject Receptors, Estrogen en
dc.subject Ribosomal Protein S6 en
dc.subject Sulfonamides en
dc.subject TOR Serine-Threonine Kinases en
dc.subject Tamoxifen en
dc.title Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifen-resistant breast cancer cells. en
dc.type Journal Article en
dc.identifier.doi 10.4161/cbt.11.11.15527 en
pubs.issue 11 en
pubs.begin-page 938 en
pubs.volume 11 en
dc.rights.holder Copyright: Landes Bioscience en
dc.identifier.pmid 21464613 en
pubs.end-page 946 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 208954 en Medical and Health Sciences en Medical Sciences en Auckland Cancer Research en Molecular Medicine en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1555-8576 en
dc.identifier.pii 15527 en
pubs.record-created-at-source-date 2012-03-03 en
pubs.dimensions-id 21464613 en

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