Mutation in Bovine beta-Carotene Oxygenase 2 Affects Milk Color

Show simple item record Knowles, Sarah en Davis, SR en Beattie, EM en Thomas, NL en Burrett, AK en Ward, HE en Stanfield, AM en Biswas, M en Ankersmit-Udy, AE en Oxley, PE en Barnett, JL en Pearson, JF en van der Does, Y en MacGibbon, AHF en Spelman, RJ en Lehnert, Klaus en Snell, Russell en 2012-02-27T00:07:34Z en 2009-07 en
dc.identifier.citation Genetics 182(3):923-926 Jul 2009 en
dc.identifier.issn 0016-6731 en
dc.identifier.uri en
dc.description.abstract β-Carotene biochemistry is a fundamental process in mammalian biology. Aberrations either through malnutrition or potentially through genetic variation may lead to vitamin A deficiency, which is a substantial public health burden. In addition, understanding the genetic regulation of this process may enable bovine improvement. While many bovine QTL have been reported, few of the causative genes and mutations have been identified. We discovered a QTL for milk b-carotene and subsequently identified a premature stop codon in bovine b-carotene oxygenase 2 (BCO2), which also affects serum b-carotene content. The BCO2 enzyme is thereby identified as a key regulator of β-carotene metabolism. en
dc.language EN en
dc.publisher Genetics Society of America en
dc.relation.ispartofseries Genetics en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: en
dc.rights.uri en
dc.subject VITAMIN-A en
dc.subject IN-VIVO en
dc.subject CLEAVAGE en
dc.subject IDENTIFICATION en
dc.subject ENZYME en
dc.subject QTL en
dc.subject YIELD en
dc.subject GENE en
dc.title Mutation in Bovine beta-Carotene Oxygenase 2 Affects Milk Color en
dc.type Journal Article en
dc.identifier.doi 10.1534/genetics.109.101741 en
pubs.issue 3 en
pubs.begin-page 923 en
pubs.volume 182 en
dc.rights.holder Copyright: Genetics Society of America en
dc.identifier.pmid 19398771 en
pubs.end-page 926 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 118298 en Science en Biological Sciences en
pubs.record-created-at-source-date 2012-02-22 en
pubs.dimensions-id 19398771 en

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