5-Substituted tetralones as inhibitors of RAS farnesyl transferase.

5-Substituted tetralones as inhibitors of RAS farnesyl transferase.

Denny, William ; Hutchings, RH ; Johnson, DS ; Koltenbronn, JS ; Lee, Ho ; Leonard, DM ; Milbank, JBJ ; Repine, JT ; Rewcastle, Gordon ; White, AD
Identifier: http://hdl.handle.net/2292/12215
Issue Date: 2005-09-13
Reference: Patent/Trademark number: US 6,943,183 (USA). Application number: 10/257,301. Filed date: 16 Apr 2001. Publication/Application date: 13 Sep 2005. Publication/Awarded date: 13 Sep 2005
Rights (URI): https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm

Abstract:

The present invention provides novel 5-substituted tetralones which are useful for treating abnormal proliferation of tissues such as cancer. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme.

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