dc.contributor.author |
Lee, Tet |
en |
dc.contributor.author |
Montgomery, Johanna |
en |
dc.contributor.author |
Birch, Nigel |
en |
dc.date.accessioned |
2012-03-01T01:10:50Z |
en |
dc.date.issued |
2012 |
en |
dc.identifier.citation |
Journal of Neurochemistry 121(4):561-574 2012 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/12390 |
en |
dc.description.abstract |
J. Neurochem. (2012) 10.1111/j.1471-4159.2011.07639.x ABSTRACT: Neuroserpin is a brain-specific serine protease inhibitor that is expressed in the developing and adult nervous system. Its expression profile led to suggestions that it played roles in neuronal growth and connectivity. In this study, we provide direct evidence to support a role for neuroserpin in axon and dendritic growth. We report that axon growth is enhanced while axon and dendrite diameter are reduced following neuroserpin treatment of hippocampal neurons. More complex effects are seen on dendritic growth and branching with neuroserpin-stimulating dendritic growth and branching in young neurons but switching to an inhibitory response in older neurons. The protease inhibitory activity of neuroserpin is not required to activate changes in neuronal morphology and a proportion of responses are modulated by an antagonist to the LRP1 receptor. Collectively, these findings support a key role for neuroserpin as a regulator of neuronal development through a non-inhibitory mechanism and suggest a basis for neuroserpin's effects on complex emotional behaviours and recent link to schizophrenia. |
en |
dc.language |
ENG |
en |
dc.publisher |
The Authors Journal of Neurochemistry |
en |
dc.relation.ispartofseries |
Journal of Neurochemistry |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
Detail obtained from http://www.sherpa.ac.uk/romeo/issn/0022-3042/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
The serine protease inhibitor neuroserpin regulates the growth and maturation of hippocampal neurons through a non-inhibitory mechanism |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1111/j.1471-4159.2011.07639.x |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
561 |
en |
pubs.volume |
121 |
en |
dc.rights.holder |
Copyright: The Authors; Journal of Neurochemistry; International Society for Neurochemistry |
en |
dc.identifier.pmid |
22191421 |
en |
pubs.end-page |
574 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
267501 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Auckland Cancer Research |
en |
pubs.org-id |
Physiology Division |
en |
dc.identifier.eissn |
1471-4159 |
en |
pubs.record-created-at-source-date |
2012-02-21 |
en |