dc.contributor.author |
Tercel, Moana |
en |
dc.contributor.author |
Atwell, Graham |
en |
dc.contributor.author |
Yang, S |
en |
dc.contributor.author |
Ashoorzadeh, Amir |
en |
dc.contributor.author |
Stevenson, Ralph |
en |
dc.contributor.author |
Botting, KJ |
en |
dc.contributor.author |
Gu, Yongchuan |
en |
dc.contributor.author |
Mehta, Sunali |
en |
dc.contributor.author |
Denny, William |
en |
dc.contributor.author |
Wilson, William |
en |
dc.contributor.author |
Pruijn, Frederik |
en |
dc.coverage.spatial |
Germany |
en |
dc.date.accessioned |
2011-11-17T17:25:20Z |
en |
dc.date.accessioned |
2012-03-01T03:31:41Z |
en |
dc.date.accessioned |
2012-03-01T21:50:34Z |
en |
dc.date.issued |
2011-03-07 |
en |
dc.identifier.citation |
Angewandte Chemie International Edition 50(11):2606-2609 07 Mar 2011 |
en |
dc.identifier.issn |
1433-7851 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/12529 |
en |
dc.description.abstract |
Hitting the hypoxic target: Combining a nitro prodrug with a water-soluble phosphate converts duocarmycin analogues from highly toxic DNA-alkylating agents to highly selective antitumor compounds. These prodrugs (see scheme) have outstanding activity against hypoxic tumor cells in vivo, cells which are usually considered the most resistant to conventional therapy. |
en |
dc.language |
eng |
en |
dc.publisher |
wiley vch verlag berlin |
en |
dc.relation.ispartofseries |
Angewandte Chemie International Edition |
en |
dc.relation.replaces |
http://hdl.handle.net/2292/9262 |
en |
dc.relation.replaces |
2292/9262 |
en |
dc.relation.replaces |
http://hdl.handle.net/2292/12435 |
en |
dc.relation.replaces |
2292/12435 |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from
http://www.sherpa.ac.uk/romeo/issn/1433-7851/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Amines |
en |
dc.subject |
Animals |
en |
dc.subject |
Anoxia |
en |
dc.subject |
Antineoplastic Agents |
en |
dc.subject |
Cell Line, Tumor |
en |
dc.subject |
Cell Survival |
en |
dc.subject |
Humans |
en |
dc.subject |
Indoles |
en |
dc.subject |
Mice |
en |
dc.subject |
Molecular Structure |
en |
dc.subject |
Prodrugs |
en |
dc.subject |
Pyrrolidinones |
en |
dc.title |
Selective treatment of hypoxic tumor cells in vivo: phosphate pre-prodrugs of nitro analogues of the duocarmycins. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1002/anie.201004456 |
en |
pubs.issue |
11 |
en |
pubs.begin-page |
2606 |
en |
pubs.volume |
50 |
en |
dc.rights.holder |
Copyright: wiley vch verlag berlin |
en |
dc.identifier.pmid |
21370347 |
en |
pubs.end-page |
2609 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
206848 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Auckland Cancer Research |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1521-3773 |
en |
pubs.record-created-at-source-date |
2011-11-17 |
en |
pubs.dimensions-id |
21370347 |
en |