Identification and expression analysis of kcnh2 genes in the zebrafish.

Show simple item record Leong, IU en Skinner, Jonathan en Shelling, Andrew en Love, Donald en
dc.coverage.spatial United States en 2012-03-01T23:43:17Z en 2010 en
dc.identifier.citation Biochemical and Biophysical Research Communications 396(4):817-824 2010 en
dc.identifier.issn 0006-291X en
dc.identifier.uri en
dc.description.abstract Long QT syndrome is a disorder that is characterised by a prolonged QT-interval and can lead to fatal cardiac arrhythmias. Many animal models have been created to study congenital long QT syndrome. Of these, zebrafish models have involved targeting two different KCNH2 gene (long QT syndrome 2) orthologues, termed zerg-2 and zerg-3, with differing cardiac phenotypes. In order to clarify this situation, this study uses a bioinformatic approach to search the current zebrafish genome sequence (Zv7 and Zv8 builds) to investigate and locate all likely zebrafish orthologues of the human KCNH2 gene. Quantitative real-time RT-PCR was also used to determine the temporal and spatial gene expression profile of the zebrafish orthologues. The data support the conclusion that zerg-2 and zerg-3 are apparent orthologues of different human genes encoding potassium ion channels, but that their functions have switched compared to the respective human proteins. en
dc.language eng en
dc.publisher Elsevier en
dc.relation.ispartofseries Biochemical and Biophysical Research Communications en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.subject Animals en
dc.subject Disease Models, Animal en
dc.subject Ether-A-Go-Go Potassium Channels en
dc.subject Gene Expression Regulation en
dc.subject Humans en
dc.subject Long QT Syndrome en
dc.subject Synteny en
dc.subject Transcription, Genetic en
dc.subject Zebrafish en
dc.subject Zebrafish Proteins en
dc.title Identification and expression analysis of kcnh2 genes in the zebrafish. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.bbrc.2010.04.157 en
pubs.issue 4 en
pubs.begin-page 817 en
pubs.volume 396 en
dc.rights.holder Copyright: Elsevier en
dc.identifier.pmid 20438705 en
pubs.end-page 824 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 119769 en Medical and Health Sciences en School of Medicine en Obstetrics and Gynaecology en
dc.identifier.eissn 1090-2104 en
dc.identifier.pii S0006-291X(10)00865-X en
pubs.record-created-at-source-date 2012-02-14 en
pubs.dimensions-id 20438705 en

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