dc.contributor.author |
Tang, JZ |
en |
dc.contributor.author |
Kong, XJ |
en |
dc.contributor.author |
Banerjee, A |
en |
dc.contributor.author |
Muniraj, N |
en |
dc.contributor.author |
Pandey, V |
en |
dc.contributor.author |
Steiner, Michael |
en |
dc.contributor.author |
Perry, Johanna |
en |
dc.contributor.author |
Zhu, T |
en |
dc.contributor.author |
Liu, Dongxu |
en |
dc.contributor.author |
Lobie, Peter |
en |
dc.date.accessioned |
2012-03-04T19:15:47Z |
en |
dc.date.issued |
2010-09 |
en |
dc.identifier.citation |
Endocrinology 151(9):4133-4145 Sep 2010 |
en |
dc.identifier.issn |
0013-7227 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/12661 |
en |
dc.description.abstract |
We herein demonstrate an oncogenic role for signal transducer and activator of transcription (STAT)-3alpha (the full length STAT3 isoform), which also mediates autocrine human GH (hGH)-stimulated oncogenicity, in human endometrial carcinoma (EC) cells. Autocrine hGH stimulated Y705 phosphorylation of STAT3 and STAT3-mediated transcriptional activity in a SRC and Janus-2 Kinase dependent manner in human EC cell lines. Forced expression of a constitutively active variant of STAT3alpha increased proliferation, anchorage-independent, three-dimensional (3D) Matrigel, and xenograft growth and promoted epithelial-mesenchymal transition, migration, and invasion of EC cells. Conversely, the oncogenic capacity of EC cells was significantly impaired by treatment with JSI-124, an inhibitor of STAT3 phosphorylation and activity, small interfering RNA-mediated depletion of STAT3alpha, or a dominant-negative variant of STAT3alpha. Furthermore, the enhanced EC cell oncogenicity stimulated by autocrine hGH, was also abrogated by functional inhibition or small interfering RNA-mediated depletion of STAT3alpha. STAT3alpha may therefore be a common mediator of oncogenic signaling pathways stimulating progression of EC. |
en |
dc.publisher |
The Endocrine Society |
en |
dc.relation.ispartofseries |
Endocrinology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: http://www.sherpa.ac.uk/romeo/issn/0013-7227/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
STAT3alpha is oncogenic for endometrial carcinoma cells and mediates the oncogenic effects of autocrine human growth hormone |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1210/en.2010-0273 |
en |
pubs.issue |
9 |
en |
pubs.begin-page |
4133 |
en |
pubs.volume |
151 |
en |
dc.rights.holder |
Copyright: The Endocrine Society |
en |
dc.identifier.pmid |
20668024 |
en |
pubs.author-url |
http://endo.endojournals.org/cgi/reprint/151/9/4133 |
en |
pubs.end-page |
4145 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
192827 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2010-12-06 |
en |
pubs.dimensions-id |
20668024 |
en |