ISSLS Prize Winner: Microstructure and Mechanical Disruption of the Lumbar Disc Annulus Part I: A Microscopic Investigation of the Translamellar Bridging Network

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dc.contributor.author Schollum, Meredith en
dc.contributor.author Robertson, PA en
dc.contributor.author Broom, Neil en
dc.date.accessioned 2012-03-04T20:21:02Z en
dc.date.issued 2008 en
dc.identifier.citation Spine (Phila Pa 1976) 33(25):2702-2710 01 Dec 2008 en
dc.identifier.issn 0362-2436 en
dc.identifier.uri http://hdl.handle.net/2292/12701 en
dc.description.abstract Study Design. Microstructural investigation of interlamellar connectivity. Objective. To reveal the macro and micro structure of the translamellar bridging network in the lumbar annulus. Summary of Background Data. Contrary to the view that there is minimal interconnection between lamellar sheets, experimental data reveal a significant contribution to the material behavior of the annulus from interactions between fiber populations of alternating lamellae. Recent microstructural studies indicate a localized rather than a homogeneous or dispersed mode of interconnectivity between lamellae. Methods. Anterior segments of ovine lumbar discs in 2 age groups were sectioned along the oblique fiber angle. A 3-dimensional picture of the translamellar bridging network is developed using structural information obtained from fully hydrated unstained serial sections imaged by differential interference contrast optics. Results. A high level of connectivity between apparently disparate bridging elements was revealed. The extended form of the bridging network is that of occasional substantial radial connections spanning many lamellae with a subsidiary fine branching network. The fibrous bridging network is highly integrated with the lamellae architecture via a collagen-based system of interconnectivity. Conclusion. This study demonstrates a far greater complexity to the interlamellar architecture of the disc annulus than has previously been recognized. Our findings are clearly relevant to disc biomechanics. Significant degrading of the translamellar bridging network may result in annular weakening leading potentially to disc failure. Most importantly this work opens the way to a much clearer understanding of the microanatomy of the disc wall. en
dc.publisher Springer Verlag en
dc.relation.ispartofseries Spine en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0362-2436/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title ISSLS Prize Winner: Microstructure and Mechanical Disruption of the Lumbar Disc Annulus Part I: A Microscopic Investigation of the Translamellar Bridging Network en
dc.type Journal Article en
dc.identifier.doi 10.1097/BRS.0b013e31817bb92c en
pubs.issue 25 en
pubs.begin-page 2702 en
pubs.volume 33 en
dc.rights.holder Copyright: Springer Verlag en
dc.identifier.pmid 19002075 en
pubs.author-url http://ovidsp.tx.ovid.com.ezproxy.auckland.ac.nz/sp-3.5.1a/ovidweb.cgi?QS2=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 en
pubs.end-page 2710 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 47463 en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 19002075 en


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