dc.contributor.author |
Payne, RJ |
en |
dc.contributor.author |
Bulloch, Esther |
en |
dc.contributor.author |
Kerbarh, O |
en |
dc.contributor.author |
Abell, C |
en |
dc.date.accessioned |
2012-03-04T23:58:28Z |
en |
dc.date.issued |
2010-08-07 |
en |
dc.identifier.citation |
Organic and Biomolecular Chemistry 8(15):3534-3542 2010 |
en |
dc.identifier.issn |
1477-0539 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/12802 |
en |
dc.description.abstract |
Several 2-amino-4-carboxypyridine, 4- and 5-carboxypyridone-based compounds were prepared and tested against three members of the chorismate-utilising enzyme family, anthranilate synthase, isochorismate synthase and salicylate synthase. Most compounds exhibited low micromolar inhibition of these three enzymes. The most potent inhibitor was a 4-carboxypyridone analogue bearing a lactate side chain on the pyridyl nitrogen which exhibited inhibition constants of 5, 91 and 54 μM against anthranilate synthase, isochorismate synthase and salicylate synthase respectively. |
en |
dc.publisher |
Royal Society of Chemistry |
en |
dc.relation.ispartofseries |
Organic & Biomolecular Chemistry |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
Details obtained from http://www.sherpa.ac.uk/romeo/issn/1477-0520/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Inhibition of chorismate-utilising enzymes by 2-amino-4-carboxypyridine and 4-carboxypyridone and 5-carboxypyridone analogues |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1039/C004062B |
en |
pubs.issue |
15 |
en |
pubs.begin-page |
3534 |
en |
pubs.volume |
8 |
en |
dc.rights.holder |
Copyright: Royal Society of Chemistry |
en |
dc.identifier.pmid |
20532401 |
en |
pubs.author-url |
http://pubs.rsc.org.ezproxy.auckland.ac.nz/en/content/articlepdf/2010/ob/c004062b |
en |
pubs.end-page |
3542 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
192715 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
pubs.record-created-at-source-date |
2010-12-06 |
en |
pubs.dimensions-id |
20532401 |
en |