Assessment of cartilage loss at the wrist in rheumatoid arthritis using a new MRI scoring system

Show simple item record

dc.contributor.author McQueen, Fiona en
dc.contributor.author Clarke, A en
dc.contributor.author McHaffie, A en
dc.contributor.author Reeves, Q en
dc.contributor.author Williams, M en
dc.contributor.author Robinson, Elizabeth en
dc.contributor.author Dong, J en
dc.contributor.author Chand, A en
dc.contributor.author Mulders, D en
dc.contributor.author Dalbeth, Nicola en
dc.date.accessioned 2012-03-06T20:46:15Z en
dc.date.issued 2010 en
dc.identifier.citation ANN RHEUM DIS 69(11):1971-1975 Nov 2010 en
dc.identifier.issn 0003-4967 en
dc.identifier.uri http://hdl.handle.net/2292/13124 en
dc.description.abstract Objectives To develop and test an MRI cartilage scoring system for use at the wrist in rheumatoid arthritis (RA). Methods MRI scans were obtained using a 3T MRI scanner with dedicated wrist coil in 22 early and 16 established RA patients plus 22 controls. Axial and coronal T1-weighted (precontrast and postcontrast) and T2-weighted turbo spin echo sequences were obtained. Eight wrist joints were scored for cartilage narrowing: distal radioulnar, radiolunate, radioscaphoid, triquetrum-hamate, capitate-lunate, scaphotrapezoid, second metacarpal base-trapezoid and third metacarpal base-capitate, using a system based on the Sharp van der Heijde x-ray joint space narrowing (JSN) score by three radiologists. Fifteen sites at the wrist were also scored for synovitis, bone oedema and erosion using the RA MRI score. Results Interobserver (three-reader) and intraobserver reliability (readers 1 and 2) for the cartilage score were excellent: intraclass correlations (ICC (95% CI)) 0.91, (0.86 to 0.94), 0.98 (0.96 to 1.00) and 0.94 (0.87 to 1.00), respectively. Cartilage scores (median, range) were higher in the established RA group (11.9, 2.3–27.3) than the early RA group (2.15, 0–6) (p≤0.001) but early RA scores did not differ from healthy controls (2.3, 1–8.7). Cartilage scores correlated with synovitis (R=0.52), bone oedema (R=0.63) and erosion scores (R=0.66), p<0.001 for all, and with x-ray JSN scores (R=0.68 to 0.78). Conclusion This MRI cartilage score demonstrated excellent reliability when tested in a three-reader system. However, cartilage loss in early RA could not be distinguished from that seen in healthy controls. en
dc.publisher BMJ Publishing Group Ltd. en
dc.relation.ispartofseries Annals of the Rheumatic Diseases en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0003-4967/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Assessment of cartilage loss at the wrist in rheumatoid arthritis using a new MRI scoring system en
dc.type Journal Article en
dc.identifier.doi 10.1136/ard.2009.127324 en
pubs.begin-page 1971 en
pubs.volume 69 en
dc.rights.holder Copyright: BMJ Publishing Group Ltd. en
dc.identifier.pmid 20472589 en
pubs.end-page 1975 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 198833 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
pubs.record-created-at-source-date 2011-01-06 en
pubs.dimensions-id 20472589 en


Files in this item

There are no files associated with this item.

Find Full text

This item appears in the following Collection(s)

Show simple item record

Share

Search ResearchSpace


Browse

Statistics