Assessment of cartilage loss at the wrist in rheumatoid arthritis using a new MRI scoring system

Show simple item record McQueen, Fiona en Clarke, A en McHaffie, A en Reeves, Q en Williams, M en Robinson, Elizabeth en Dong, J en Chand, A en Mulders, D en Dalbeth, Nicola en 2012-03-06T20:46:15Z en 2010 en
dc.identifier.citation ANN RHEUM DIS 69(11):1971-1975 Nov 2010 en
dc.identifier.issn 0003-4967 en
dc.identifier.uri en
dc.description.abstract Objectives To develop and test an MRI cartilage scoring system for use at the wrist in rheumatoid arthritis (RA). Methods MRI scans were obtained using a 3T MRI scanner with dedicated wrist coil in 22 early and 16 established RA patients plus 22 controls. Axial and coronal T1-weighted (precontrast and postcontrast) and T2-weighted turbo spin echo sequences were obtained. Eight wrist joints were scored for cartilage narrowing: distal radioulnar, radiolunate, radioscaphoid, triquetrum-hamate, capitate-lunate, scaphotrapezoid, second metacarpal base-trapezoid and third metacarpal base-capitate, using a system based on the Sharp van der Heijde x-ray joint space narrowing (JSN) score by three radiologists. Fifteen sites at the wrist were also scored for synovitis, bone oedema and erosion using the RA MRI score. Results Interobserver (three-reader) and intraobserver reliability (readers 1 and 2) for the cartilage score were excellent: intraclass correlations (ICC (95% CI)) 0.91, (0.86 to 0.94), 0.98 (0.96 to 1.00) and 0.94 (0.87 to 1.00), respectively. Cartilage scores (median, range) were higher in the established RA group (11.9, 2.3–27.3) than the early RA group (2.15, 0–6) (p≤0.001) but early RA scores did not differ from healthy controls (2.3, 1–8.7). Cartilage scores correlated with synovitis (R=0.52), bone oedema (R=0.63) and erosion scores (R=0.66), p<0.001 for all, and with x-ray JSN scores (R=0.68 to 0.78). Conclusion This MRI cartilage score demonstrated excellent reliability when tested in a three-reader system. However, cartilage loss in early RA could not be distinguished from that seen in healthy controls. en
dc.publisher BMJ Publishing Group Ltd. en
dc.relation.ispartofseries Annals of the Rheumatic Diseases en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Assessment of cartilage loss at the wrist in rheumatoid arthritis using a new MRI scoring system en
dc.type Journal Article en
dc.identifier.doi 10.1136/ard.2009.127324 en
pubs.begin-page 1971 en
pubs.volume 69 en
dc.rights.holder Copyright: BMJ Publishing Group Ltd. en
dc.identifier.pmid 20472589 en
pubs.end-page 1975 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 198833 en Medical and Health Sciences en School of Medicine en Medicine Department en
pubs.record-created-at-source-date 2011-01-06 en
pubs.dimensions-id 20472589 en

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