Changes in elastin, elastin binding protein and versican in alveoli in chronic obstructive pulmonary disease.

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dc.contributor.author Merrilees, Mervyn en
dc.contributor.author Ching, Pamela en
dc.contributor.author Beaumont, Brent en
dc.contributor.author Hinek, A en
dc.contributor.author Wight, TN en
dc.contributor.author Black, Peter en
dc.date.accessioned 2012-03-07T00:17:06Z en
dc.date.issued 2008 en
dc.identifier.citation RESP RES 9: Article number 41 18 May 2008 en
dc.identifier.issn 1465-9921 en
dc.identifier.uri http://hdl.handle.net/2292/13177 en
dc.description.abstract COPD is characterised by loss of alveolar elastic fibers and by lack of effective repair. Elastic fibers are assembled at cell surfaces by elastin binding protein (EBP), a molecular chaperone whose function can be reversibility inhibited by chondroitin sulphate of matrix proteoglycans such as versican. This study aimed to determine if alveoli of patients with mild to moderate COPD contained increased amounts of versican and a corresponding decrease in EBP, and if these changes were correlated with decreases in elastin and FEV1. en
dc.publisher BioMed Central Ltd. en
dc.relation.ispartofseries Respiratory Research en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1465-9921/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Changes in elastin, elastin binding protein and versican in alveoli in chronic obstructive pulmonary disease. en
dc.type Journal Article en
dc.identifier.doi 10.1186/1465-9921-9-41 en
pubs.issue 1 en
pubs.begin-page 41 en
pubs.volume 9 en
dc.rights.holder Copyright: BioMed Central Ltd. en
dc.identifier.pmid 18485243 en
pubs.end-page 49 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 83744 en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 18485243 en


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