dc.contributor.author |
Merrilees, Mervyn |
en |
dc.contributor.author |
Ching, Pamela |
en |
dc.contributor.author |
Beaumont, Brent |
en |
dc.contributor.author |
Hinek, A |
en |
dc.contributor.author |
Wight, TN |
en |
dc.contributor.author |
Black, Peter |
en |
dc.date.accessioned |
2012-03-07T00:17:06Z |
en |
dc.date.issued |
2008 |
en |
dc.identifier.citation |
RESP RES 9: Article number 41 18 May 2008 |
en |
dc.identifier.issn |
1465-9921 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/13177 |
en |
dc.description.abstract |
COPD is characterised by loss of alveolar elastic fibers and by lack of effective repair. Elastic fibers are assembled at cell surfaces by elastin binding protein (EBP), a molecular chaperone whose function can be reversibility inhibited by chondroitin sulphate of matrix proteoglycans such as versican. This study aimed to determine if alveoli of patients with mild to moderate COPD contained increased amounts of versican and a corresponding decrease in EBP, and if these changes were correlated with decreases in elastin and FEV1. |
en |
dc.publisher |
BioMed Central Ltd. |
en |
dc.relation.ispartofseries |
Respiratory Research |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1465-9921/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Changes in elastin, elastin binding protein and versican in alveoli in chronic obstructive pulmonary disease. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1186/1465-9921-9-41 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
41 |
en |
pubs.volume |
9 |
en |
dc.rights.holder |
Copyright: BioMed Central Ltd. |
en |
dc.identifier.pmid |
18485243 |
en |
pubs.end-page |
49 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
83744 |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
18485243 |
en |