Neointima formed by arterial smooth muscle cells expressing versican variant V3 is resistant to lipid and macrophage accumulation

Merrilees, Mervyn; Beaumont, BW; Braun, KR; Thomas, AC; Kang, I; Hinek, A; Passi, AP; Wight, TN

dc.contributor.author	Merrilees, Mervyn	en
dc.contributor.author	Beaumont, BW	en
dc.contributor.author	Braun, KR	en
dc.contributor.author	Thomas, AC	en
dc.contributor.author	Kang, I	en
dc.contributor.author	Hinek, A	en
dc.contributor.author	Passi, AP	en
dc.contributor.author	Wight, TN	en
dc.date.accessioned	2012-03-07T00:22:33Z	en
dc.date.issued	2011	en
dc.identifier.citation	Arteriosclerosis, Thrombosis, and Vascular Biology 31:1309-1316 2011	en
dc.identifier.issn	1079-5642	en
dc.identifier.uri	http://hdl.handle.net/2292/13179	en
dc.description.abstract	Extracellular matrix (ECM) of neointima formed following angioplasty contains elevated levels of versican, loosely arranged collagen, and fragmented deposits of elastin, features associated with lipid and macrophage accumulation. ECM with a low versican content, compact structure, and increased elastic fiber content can be achieved by expression of versican variant V3, which lacks chondroitin sulfate glycosaminoglycans. We hypothesized that V3-expressing arterial smooth muscle cells (ASMC) can be used to form a neointima resistant to lipid and macrophage accumulation associated with hypercholesterolemia.	en
dc.publisher	American Heart Association, Inc.	en
dc.relation.ispartofseries	Arteriosclerosis, Thrombosis, and Vascular Biology	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.title	Neointima formed by arterial smooth muscle cells expressing versican variant V3 is resistant to lipid and macrophage accumulation	en
dc.type	Journal Article	en
dc.identifier.doi	10.1161/ATVBAHA.111.225573	en
pubs.begin-page	1309	en
pubs.volume	31	en
dc.rights.holder	Copyright: American Heart Association, Inc.	en
dc.identifier.pmid	21441139	en
pubs.end-page	1316	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	210627	en
pubs.record-created-at-source-date	2011-05-30	en
pubs.dimensions-id	21441139	en