dc.contributor.author |
Young, Robert |
en |
dc.contributor.author |
Hopkins, RJ |
en |
dc.contributor.author |
Christmas, T |
en |
dc.contributor.author |
Metcalf, Patricia |
en |
dc.contributor.author |
Gamble, GD |
en |
dc.date.accessioned |
2012-03-07T00:59:30Z |
en |
dc.date.issued |
2009 |
en |
dc.identifier.citation |
Eur Respir J 34(2):380-386 Aug 2009 |
en |
dc.identifier.issn |
0903-1936 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/13192 |
en |
dc.description.abstract |
Chronic obstructive pulmonary disease (COPD) is a common comorbid disease in lung cancer, estimated to affect 40–70% of lung cancer patients, depending on diagnostic criteria. As smoking exposure is found in 85–90% of those diagnosed with either COPD or lung cancer, coexisting disease could merely reflect a shared smoking exposure. Potential confounding by age, sex and pack-yr smoking history, and/or by the possible effects of lung cancer on spirometry, may result in over-diagnosis of COPD prevalence. In the present study, the prevalence of COPD (pre-bronchodilator Global Initiative for Chronic Obstructive Lung Disease 2+ criteria) in patients diagnosed with lung cancer was 50% compared with 8% in a randomly recruited community control group, matched for age, sex and pack-yr smoking exposure (n = 602, odds ratio 11.6; p<0.0001). In a subgroup analysis of those with lung cancer and lung function measured prior to the diagnosis of lung cancer (n = 127), we found a nonsignificant increase in COPD prevalence following diagnosis (56–61%; p = 0.45). After controlling for important variables, the prevalence of COPD in newly diagnosed lung cancer cases was six-fold greater than in matched smokers; this is much greater than previously reported. We conclude that COPD is both a common and important independent risk factor for lung cancer. |
en |
dc.publisher |
European Respiratory Society Journals Ltd. |
en |
dc.relation.ispartofseries |
European Respiratory Journal |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0903-1936/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
COPD prevalence is increased in lung cancer, independent of age, sex and smoking history. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1183/09031936.00144208 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
380 |
en |
pubs.volume |
34 |
en |
dc.rights.holder |
Copyright: European Respiratory Society Journals Ltd. |
en |
dc.identifier.pmid |
19196816 |
en |
pubs.end-page |
386 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
99297 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Statistics |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
19196816 |
en |