How should we construct psychiatric family history scores? A comparison of alternative approaches from the Dunedin Family Health History Study

Show simple item record Milne, Barry en Moffitt, TE en Crump, R en Poulton, R en Rutter, M en Sears, MR en Taylor, A en Caspi, A en 2012-03-07T21:27:06Z en 2008-12 en
dc.identifier.citation Psychological Medicine 38(12):1793-1802 Dec 2008 en
dc.identifier.issn 0033-2917 en
dc.identifier.uri en
dc.description.abstract Background There is increased interest in assessing the family history of psychiatric disorders for both genetic research and public health screening. It is unclear how best to combine family history reports into an overall score. We compare the predictive validity of different family history scores. Method Probands from the Dunedin Study (n=981, 51% male) had their family history assessed for nine different conditions. We computed four family history scores for each disorder: (1) a simple dichotomous categorization of whether or not probands had any disordered first-degree relatives; (2) the observed number of disordered first-degree relatives; (3) the proportion of first-degree relatives who are disordered; and (4) Reed's score, which expressed the observed number of disordered first-degree relatives in terms of the number expected given the age and sex of each relative. We compared the strength of association between each family history score and probands' disorder outcome. Results Each score produced significant family history associations for all disorders. The scores that took account of the number of disordered relatives within families (i.e. the observed, proportion, and Reed's scores) produced significantly stronger associations than the dichotomous score for conduct disorder, alcohol dependence and smoking. Taking account of family size (i.e. using the proportion or Reed's score) produced stronger family history associations depending on the prevalence of the disorder among family members. Conclusions Dichotomous family history scores can be improved upon by considering the number of disordered relatives in a family and the population prevalence of the disorder. en
dc.language EN en
dc.publisher Cambridge University Press en
dc.relation.ispartofseries Psychological Medicine en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.subject Family history en
dc.subject predictive validity en
dc.subject prevalence en
dc.subject psychiatry en
dc.subject BIRTH RISK-FACTORS en
dc.subject DIRECT INTERVIEW en
dc.subject SUBSTANCE-ABUSE en
dc.subject MENTAL-DISORDER en
dc.subject SCREENING-TEST en
dc.subject HEART-DISEASE en
dc.subject CO-MORBIDITY en
dc.title How should we construct psychiatric family history scores? A comparison of alternative approaches from the Dunedin Family Health History Study en
dc.type Journal Article en
dc.identifier.doi 10.1017/S0033291708003115 en
pubs.issue 12 en
pubs.begin-page 1793 en
pubs.volume 38 en
dc.rights.holder Copyright: Cambridge University Press en
dc.identifier.pmid 18366822 en
pubs.end-page 1802 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 161342 en Arts en Arts Research en Compass en
pubs.record-created-at-source-date 2012-02-16 en
pubs.dimensions-id 18366822 en

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