dc.contributor.author |
Milne, Barry |
en |
dc.contributor.author |
Moffitt, TE |
en |
dc.contributor.author |
Crump, R |
en |
dc.contributor.author |
Poulton, R |
en |
dc.contributor.author |
Rutter, M |
en |
dc.contributor.author |
Sears, MR |
en |
dc.contributor.author |
Taylor, A |
en |
dc.contributor.author |
Caspi, A |
en |
dc.date.accessioned |
2012-03-07T21:27:06Z |
en |
dc.date.issued |
2008-12 |
en |
dc.identifier.citation |
Psychological Medicine 38(12):1793-1802 Dec 2008 |
en |
dc.identifier.issn |
0033-2917 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/13326 |
en |
dc.description.abstract |
Background There is increased interest in assessing the family history of psychiatric disorders for both genetic research and public health screening. It is unclear how best to combine family history reports into an overall score. We compare the predictive validity of different family history scores. Method Probands from the Dunedin Study (n=981, 51% male) had their family history assessed for nine different conditions. We computed four family history scores for each disorder: (1) a simple dichotomous categorization of whether or not probands had any disordered first-degree relatives; (2) the observed number of disordered first-degree relatives; (3) the proportion of first-degree relatives who are disordered; and (4) Reed's score, which expressed the observed number of disordered first-degree relatives in terms of the number expected given the age and sex of each relative. We compared the strength of association between each family history score and probands' disorder outcome. Results Each score produced significant family history associations for all disorders. The scores that took account of the number of disordered relatives within families (i.e. the observed, proportion, and Reed's scores) produced significantly stronger associations than the dichotomous score for conduct disorder, alcohol dependence and smoking. Taking account of family size (i.e. using the proportion or Reed's score) produced stronger family history associations depending on the prevalence of the disorder among family members. Conclusions Dichotomous family history scores can be improved upon by considering the number of disordered relatives in a family and the population prevalence of the disorder. |
en |
dc.language |
EN |
en |
dc.publisher |
Cambridge University Press |
en |
dc.relation.ispartofseries |
Psychological Medicine |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0033-2917/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Family history |
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dc.subject |
predictive validity |
en |
dc.subject |
prevalence |
en |
dc.subject |
psychiatry |
en |
dc.subject |
GENERALIZED ANXIETY DISORDER |
en |
dc.subject |
TRAUMATIC LIFE EVENTS |
en |
dc.subject |
BIRTH RISK-FACTORS |
en |
dc.subject |
DIRECT INTERVIEW |
en |
dc.subject |
ALCOHOL DEPENDENCE |
en |
dc.subject |
SUBSTANCE-ABUSE |
en |
dc.subject |
MENTAL-DISORDER |
en |
dc.subject |
SCREENING-TEST |
en |
dc.subject |
HEART-DISEASE |
en |
dc.subject |
CO-MORBIDITY |
en |
dc.title |
How should we construct psychiatric family history scores? A comparison of alternative approaches from the Dunedin Family Health History Study |
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dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1017/S0033291708003115 |
en |
pubs.issue |
12 |
en |
pubs.begin-page |
1793 |
en |
pubs.volume |
38 |
en |
dc.rights.holder |
Copyright: Cambridge University Press |
en |
dc.identifier.pmid |
18366822 |
en |
pubs.end-page |
1802 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
161342 |
en |
pubs.org-id |
Arts |
en |
pubs.org-id |
Arts Research |
en |
pubs.org-id |
Compass |
en |
pubs.record-created-at-source-date |
2012-02-16 |
en |
pubs.dimensions-id |
18366822 |
en |