dc.contributor.author |
Mitchell, Simon |
en |
dc.contributor.author |
Doolette, DJ |
en |
dc.coverage.spatial |
United States |
en |
dc.date.accessioned |
2012-03-07T22:13:08Z |
en |
dc.date.issued |
2009-01 |
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dc.identifier.citation |
Journal of Applied Physiology 106(1):298-301 Jan 2009 |
en |
dc.identifier.issn |
8750-7587 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/13345 |
en |
dc.description.abstract |
Inner ear decompression sickness has been strongly associated with the presence of right-to-left shunts. The implied involvement of intravascular bubbles shunted from venous to arterial circulations is inconsistent with the frequent absence of cerebral symptoms in these cases. If arterial bubbles reach the labyrinthine artery, they must also be distributing widely in the brain. This discrepancy could be explained by slower inert gas washout from the inner ear after diving and the consequent tendency for arterial bubbles entering this supersaturated territory to grow because of inward diffusion of gas. Published models for inner ear and brain inert gas kinetics were used to predict tissue gas tensions after an air dive to 4 atm absolute for 25 min. The models predict half-times for nitrogen washout of 8.8 min and 1.2 min for the inner ear and brain, respectively. The inner ear remains supersaturated with nitrogen for longer after diving than the brain, and in the simulated dive, for a period that corresponds with the latency of typical cases. It is therefore plausible that prolonged inner ear inert gas supersaturation contributes to the selective vulnerability of the inner ear to short latency decompression sickness in divers with right-to-left shunt. |
en |
dc.language |
eng |
en |
dc.publisher |
American Physiological Society |
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dc.relation.ispartofseries |
Journal of Applied Physiology |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
Adaptation, Physiological |
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dc.subject |
Brain |
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dc.subject |
Computer Simulation |
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dc.subject |
Decompression Sickness |
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dc.subject |
Diffusion |
en |
dc.subject |
Diving |
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dc.subject |
Ear, Inner |
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dc.subject |
Embolism, Air |
en |
dc.subject |
Foramen Ovale, Patent |
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dc.subject |
Humans |
en |
dc.subject |
Kinetics |
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dc.subject |
Labyrinth Diseases |
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dc.subject |
Models, Biological |
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dc.subject |
Nitrogen |
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dc.subject |
Partial Pressure |
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dc.subject |
Reaction Time |
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dc.title |
Selective vulnerability of the inner ear to decompression sickness in divers with right-to-left shunt: the role of tissue gas supersaturation. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1152/japplphysiol.90915.2008 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
298 |
en |
pubs.volume |
106 |
en |
dc.rights.holder |
Copyright: American Physiological Society |
en |
dc.identifier.pmid |
18801958 |
en |
pubs.end-page |
301 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
222022 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Anaesthesiology |
en |
dc.identifier.pii |
90915.2008 |
en |
pubs.record-created-at-source-date |
2012-02-13 |
en |
pubs.dimensions-id |
18801958 |
en |