Electrochemically controlled drug delivery based on intrinsically conducting polymers.

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dc.contributor.author Svirskis, Darren en
dc.contributor.author Travas-Sejdic, Jadranka en
dc.contributor.author Rodgers, A en
dc.contributor.author Garg, Sanjay en
dc.coverage.spatial Netherlands en
dc.date.accessioned 2012-03-07T22:15:34Z en
dc.date.issued 2010 en
dc.identifier.citation Journal of Controlled Release 146(1):6-15 2010 en
dc.identifier.issn 0168-3659 en
dc.identifier.uri http://hdl.handle.net/2292/13348 en
dc.description.abstract This paper reviews the application of intrinsically conducting polymers (ICPs) in drug delivery. ICPs are organic polymers with electrical, magnetic and optical properties usually associated with metals, whilst retaining the advantageous mechanical properties and ease of processing usually associated with polymers. Due to the inherent properties of these unique materials, electrical stimulation can be used to alter the redox state of ICPs, which in turn can modify the release rate of drug. The controlled release of drugs from ICPs has been reported in the literature since the 1980s. Following continued development, clinical applications of ICP-based drug delivery systems (DDS) have been reported recently. The next generation of controlled release technologies could utilise the biosensing properties of ICPs combined with their drug delivering abilities to develop an intelligent drug delivery system from a single material where the release rate of drug self adjusts in response to a sensed change in local body environment. This article provides an overview of ICP synthesis and properties relevant to their use as DDS, including biodegradability and biocompatibility, followed by literature on ICP-based DDS examining different methods of drug incorporation and release. The pharmaceutical applications of these systems have also been discussed. It is concluded that ICPs hold great promise in drug delivering implants where the dose can be adjusted through application of external stimulus, thus optimising benefit to side effect ratio while simultaneously ensuring patient adherence. en
dc.language eng en
dc.publisher Elsevier en
dc.relation.ispartofseries Journal of Controlled Release en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: http://www.sherpa.ac.uk/romeo/issn/0168-3659/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Animals en
dc.subject Anions en
dc.subject Biocompatible Materials en
dc.subject Cations en
dc.subject Delayed-Action Preparations en
dc.subject Drug Carriers en
dc.subject Drug Compounding en
dc.subject Electric Conductivity en
dc.subject Electrochemistry en
dc.subject Humans en
dc.subject Molecular Structure en
dc.subject Polymers en
dc.subject Pyrroles en
dc.subject Static Electricity en
dc.subject Surface Properties en
dc.title Electrochemically controlled drug delivery based on intrinsically conducting polymers. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.jconrel.2010.03.023 en
pubs.issue 1 en
pubs.begin-page 6 en
pubs.volume 146 en
dc.rights.holder Copyright: Elsevier en
dc.identifier.pmid 20359512 en
pubs.end-page 15 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Review en
pubs.elements-id 120121 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Pharmacy en
pubs.org-id Science en
pubs.org-id Chemistry en
dc.identifier.eissn 1873-4995 en
dc.identifier.pii S0168-3659(10)00228-2 en
pubs.record-created-at-source-date 2012-02-27 en
pubs.dimensions-id 20359512 en

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