Abstract:
The effect of mouse interferon on the primary in vitro antibody
response of mouse spleen cells against sheep erythrocytes was studied.
Concentrations of interferon greater than 8 units/rJl significantly
inhibited the antibody response while low conceentrations of
0.08 - 0.8 units/ml were mildly enhancing. No effect on cell
viability was observed with any of the interferon concentrations.
The effects were specific for mouse interferon as human interferon
had no effect on the antibody response of mouse spleen cells.