Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes 1997 - 2009

Show simple item record Mountjoy, Kathleen en 2012-03-08T19:10:19Z en 2010 en
dc.identifier.citation BIOCHEM J 428:305-324 15 Jun 2010 en
dc.identifier.issn 0264-6021 en
dc.identifier.uri en
dc.description.abstract Melanocortin peptides, derived from POMC (pro-opiomelanocortin) are produced in the ARH (arcuate nucleus of the hypothalamus) neurons and the neurons in the commissural NTS (nucleus of the solitary tract) of the brainstem, in anterior and intermediate lobes of the pituitary, skin and a wide range of peripheral tissues, including reproductive organs. A hypothetical model for functional roles of melanocortin receptors in maintaining energy balance was proposed in 1997. Since this time, there has been an extraordinary amount of knowledge gained about POMC-derived peptides in relation to energy homoeostasis. Development of a Pomc-null mouse provided definitive proof that POMC-derived peptides are critical for the regulation of energy homoeostasis. The melanocortin system consists of endogenous agonists and antagonists, five melanocortin receptor subtypes and receptor accessory proteins. The melanocortin system, as is now known, is far more complex than most of us could have imagined in 1997, and, similarly, the importance of this system for regulating energy homoeostasis in the general human population is much greater than we would have predicted. Of the known factors that can cause human obesity, or protect against it, the melanocortin system is by far the most significant. The present review is a discussion of the current understanding of the roles and mechanism of action of POMC, melanocortin receptors and AgRP (agouti-related peptide) in obesity and Type 2 diabetes and how the central and/or peripheral melanocortin systems mediate nutrient, leptin, insulin, gut hormone and cytokine regulation of energy homoeostasis. en
dc.publisher Biochemical Society en
dc.relation.ispartofseries Biochemical Journal en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes 1997 - 2009 en
dc.type Journal Article en
dc.identifier.doi 10.1042/BJ20091957 en
pubs.begin-page 305 en
pubs.volume 428 en
dc.rights.holder Copyright: Biochemical Society en
dc.identifier.pmid 20504281 en
pubs.end-page 324 en
dc.rights.accessrights en
pubs.subtype Review en
pubs.elements-id 100279 en Medical and Health Sciences en Medical Sciences en Physiology Division en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 20504281 en

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