dc.contributor.author |
Murphy, Kelly |
en |
dc.contributor.author |
Hall, CL |
en |
dc.contributor.author |
McCue, SW |
en |
dc.contributor.author |
McElwain, DLS |
en |
dc.date.accessioned |
2012-03-08T19:37:25Z |
en |
dc.date.issued |
2011-03-07 |
en |
dc.identifier.citation |
J Theor Biol 272(1):145-159 07 Mar 2011 |
en |
dc.identifier.issn |
0022-5193 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/13492 |
en |
dc.description.abstract |
The repair of dermal tissue is a complex process of interconnected phenomena, where cellular, chemical and mechanical aspects all play a role, both in an autocrine and in a paracrine fashion. Recent experimental results have shown that transforming growth factor -β (TGFβ) and tissue mechanics play roles in regulating cell proliferation, differentiation and the production of extracellular materials. We have developed a 1D mathematical model that considers the interaction between the cellular, chemical and mechanical phenomena, allowing the combination of TGFβ and tissue stress to inform the activation of fibroblasts to myofibroblasts. Additionally, our model incorporates the observed feature of residual stress by considering the changing zero-stress state in the formulation for effective strain. Using this model, we predict that the continued presence of TGFβ in dermal wounds will produce contractures due to the persistence of myofibroblasts; in contrast, early elimination of TGFβ significantly reduces the myofibroblast numbers resulting in an increase in wound size. Similar results were obtained by varying the rate at which fibroblasts differentiate to myofibroblasts and by changing the myofibroblast apoptotic rate. Taken together, the implication is that elevated levels of myofibroblasts is the key factor behind wounds healing with excessive contraction, suggesting that clinical strategies which aim to reduce the myofibroblast density may reduce the appearance of contractures. |
en |
dc.language |
English |
en |
dc.publisher |
Elsevier Ltd |
en |
dc.relation.ispartofseries |
Journal of Theoretical Biology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0022-5193/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Biomechanics |
en |
dc.subject |
Morphoelasticity |
en |
dc.subject |
Zero stress states |
en |
dc.subject |
Myofibroblasts |
en |
dc.title |
A two-compartment mechanochemical model of the roles of transforming growth factor β and tissue tension in dermal wound healing |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.jtbi.2010.12.011 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
145 |
en |
pubs.volume |
272 |
en |
dc.rights.holder |
Copyright: Elsevier Ltd |
en |
dc.identifier.pmid |
21168423 |
en |
pubs.end-page |
159 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
209332 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.record-created-at-source-date |
2011-04-29 |
en |
pubs.dimensions-id |
21168423 |
en |