A retrospective study of the impact of lifestyle on age at onset of Huntington disease

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dc.contributor.author Trembath, KM en
dc.contributor.author Horton, Z en
dc.contributor.author Tippett, Lynette en
dc.contributor.author Hogg, Mary en
dc.contributor.author Collins, VR en
dc.contributor.author Churchyard, A en
dc.contributor.author Velakoulis, D en
dc.contributor.author Roxburgh, Richard en
dc.contributor.author Delatycki, MB en
dc.date.accessioned 2012-03-11T20:51:42Z en
dc.date.issued 2010 en
dc.identifier.citation Movement Disorders 25(10):1444-1450 30 Jul 2010 en
dc.identifier.issn 0885-3185 en
dc.identifier.uri http://hdl.handle.net/2292/13694 en
dc.description.abstract In transgenic mouse models of Huntington disease (HD) environmental enrichment significantly delays disease onset. A questionnaire-based survey of 154 adults with diagnosed HD (mean 4.2 years postdiagnosis) and a known IT15 CAG repeat length, explored whether premorbid lifestyle may relate to age-at-onset (AO). Participants were drawn from HD outpatient clinics in Australia and New Zealand. Premorbid physical, intellectual, and passive activity levels were used to generate scores in the categories of leisure, nonleisure (education, occupation and domestic duties) and total lifestyle. AO was associated with increased CAG repeat length as expected (r 5 20.72, P < 0.001), but also with a lifestyle that included higher levels of passive activity (r 5 20.38, P < 0.001). Multiple linear regression modeling showed lifestyle passivity to be a variable independent of CAG repeat length in predicting AO (R2 5 0.54, b 5 20.22, P 5 0.005). Comparison of the mean AO across tertiles of lifestyle passivity scores showed onset 4.6 years (95% CI 5 1.3–7.9) later in the least compared with the most passive tertile. CAG repeat length was also shown to predict lifestyle passivity (R2 5 0.12, b 5 1.08, P < 0.0005). Neither intellectual nor physical activity showed significant relationships to AO or CAG repeat length in this cohort. Our study leads to two conclusions: that a passive lifestyle may be a preclinical expression of HD, and that it actually contributes to the earlier onset of symptoms. Overcoming the tendency to be passive may substantially delay onset of HD. 2010 Movement Disorder Society en
dc.publisher Wiley-Blackwell en
dc.relation.ispartofseries Movement Disorders en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: http://www.sherpa.ac.uk/romeo/issn/0885-3185/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title A retrospective study of the impact of lifestyle on age at onset of Huntington disease en
dc.type Journal Article en
dc.identifier.doi 10.1002/mds.23108 en
pubs.issue 10 en
pubs.begin-page 1444 en
pubs.volume 25 en
dc.rights.holder Copyright: Wiley-Blackwell en
dc.identifier.pmid 20629137 en
pubs.end-page 1450 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 98258 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
pubs.org-id Science en
pubs.org-id Psychology en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 20629137 en

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