dc.contributor.author |
Murphy, Rinki |
en |
dc.contributor.author |
Tura, A |
en |
dc.contributor.author |
Clark, P |
en |
dc.contributor.author |
Holst, JJ |
en |
dc.contributor.author |
Mari, A |
en |
dc.contributor.author |
Hattersley, AT |
en |
dc.date.accessioned |
2012-03-12T02:19:50Z |
en |
dc.date.issued |
2009 |
en |
dc.identifier.citation |
Diabetologia 52(1):154-159 2009 |
en |
dc.identifier.issn |
0012-186X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/13832 |
en |
dc.description.abstract |
The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotrophic peptide (GIP) are released from intestinal endocrine cells in response to luminal glucose. Glucokinase is present in these cells and has been proposed as a glucose sensor. The physiological role of glucokinase can be tested using individuals with heterozygous glucokinase gene (GCK) mutations. If glucokinase is the gut glucose sensor, GLP-1 and GIP secretion during a 75 g OGTT would be lower in GCK mutation carriers compared with controls. |
en |
dc.publisher |
Springer Verlag |
en |
dc.relation.ispartofseries |
Diabetologia |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0012-186X/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Glucokinase, the pancreatic glucose sensor is not the gut glucose sensor |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1007/s00125-008-1183-9 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
154 |
en |
pubs.volume |
52 |
en |
dc.rights.holder |
Copyright: Springer Verlag |
en |
dc.identifier.pmid |
18974968 |
en |
pubs.end-page |
159 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
83039 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
18974968 |
en |