dc.contributor.author |
Zargar Shoshtari, Kamran |
en |
dc.contributor.author |
Sammour, T |
en |
dc.contributor.author |
Kahokehr, A |
en |
dc.contributor.author |
Connolly, AB |
en |
dc.contributor.author |
Hill, Andrew |
en |
dc.coverage.spatial |
England |
en |
dc.date.accessioned |
2012-03-12T02:26:03Z |
en |
dc.date.issued |
2009-11-01 |
en |
dc.identifier.citation |
BRITISH JOURNAL OF SURGERY 96(11):1253-1261 01 Nov 2009 |
en |
dc.identifier.issn |
0007-1323 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/13899 |
en |
dc.description.abstract |
Background: Recent data have Suggested a relationship between Postoperative fatigue and the peritoneal cytokine response after surgery. The aim of this study was to test the hypothesis that preoperative administration of glucocorticoids before surgery would decrease fatigue and enhance recovery, by reducing the peritoneal production of cytokines.Methods: In a double-blind randomized controlled study, patients undergoing elective, open colonic resection were administered 8 mg dexamethasone or normal saline. Patients were treated within all enhanced recovery after surgery programme. Primary outcomes were cytokine levels in peritoneal drain fluid and fatigue as measured by the Identity-Consequence Fatigue Scale (ICFS).Results: Baseline parameters were similar for 29 patients in the dexamethasone group and 31 in the Placebo g-roup. Patients who received dexamethasone had lower ICFS scores on days 3 and 7. Dexamethasone was associated with significantly lower peritoneal fluid interleukin (IL) 6 and IL-13 concentrations oil clay 1, and these correlated with changes in the ICFS score. There was no significant increase in adverse events ill the group.Conclusion: Preoperative administration of dexamethasone resulted in a significant reduction ill early postoperative fatigue, associated with an attenuated early peritoneal cytokine response. Peritoneal production of cytokines may therefore lie important in postoperative recovery. Registration number: ACTRN12607000066482 (htttp://www.anzctr.org.au/). |
en |
dc.language |
English |
en |
dc.publisher |
2009 British Journal of Surgery Society Ltd. |
en |
dc.relation.ispartofseries |
British Journal of Surgery |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Science & Technology |
en |
dc.subject |
Life Sciences & Biomedicine |
en |
dc.subject |
Surgery |
en |
dc.subject |
MAJOR ABDOMINAL-SURGERY |
en |
dc.subject |
TISSUE OXYGEN-TENSION |
en |
dc.subject |
COLONIC SURGERY |
en |
dc.subject |
COLORECTAL SURGERY |
en |
dc.subject |
EPIDURAL ANALGESIA |
en |
dc.subject |
SYSTEMIC RESPONSE |
en |
dc.subject |
SURGICAL PATIENTS |
en |
dc.subject |
FATIGUE |
en |
dc.subject |
DEXAMETHASONE |
en |
dc.subject |
NAUSEA |
en |
dc.title |
Randomized clinical trial of the effect of glucocorticoids on peritoneal inflammation and postoperative recovery after colectomy |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1002/bjs.6744 |
en |
pubs.issue |
11 |
en |
pubs.begin-page |
1253 |
en |
pubs.volume |
96 |
en |
dc.rights.holder |
Copyright: 2009 British Journal of Surgery Society Ltd. |
en |
dc.identifier.pmid |
19847865 |
en |
pubs.author-url |
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000271556900005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d |
en |
pubs.end-page |
1261 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
118274 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
South Auckland clinical school |
en |
pubs.org-id |
Surgery Department |
en |
dc.identifier.eissn |
1365-2168 |
en |
pubs.record-created-at-source-date |
2012-08-10 |
en |
pubs.dimensions-id |
19847865 |
en |