dc.contributor.author |
Walker, CS |
en |
dc.contributor.author |
Conner, AC |
en |
dc.contributor.author |
Poyner, DR |
en |
dc.contributor.author |
Hay, DL |
en |
dc.date.accessioned |
2012-03-12T20:12:24Z |
en |
dc.date.available |
2012-03-12T20:12:24Z |
en |
dc.date.issued |
2010 |
en |
dc.identifier.citation |
Trends in Pharmacological Sciences 31(10):476-483 2010 |
en |
dc.identifier.issn |
0165-6147 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/13976 |
en |
dc.description.abstract |
Calcitonin gene-related peptide (CGRP) plays a pivotal role in migraine, activating its cognate receptor to initiate intracellular signalling. This atypical receptor comprises a distinct assembly, made up of a G protein-coupled receptor (GPCR), a single transmembrane protein, and an additional protein that is required for Gα_{s} coupling. By altering the expression of individual receptor components, it might be possible to adjust cellular sensitivity to CGRP. In recognition of the increasing clinical significance of CGRP receptors, it is timely to review the signalling pathways that might be controlled by this receptor, how the activity of the receptor itself is regulated, and our current understanding of the molecular mechanisms involved in these processes. Like many GPCRs, the CGRP receptor appears to be promiscuous, potentially coupling to several G proteins and intracellular pathways. Their precise composition is likely to be cell type–dependent, and much work is needed to ascertain their physiological significance. |
en |
dc.publisher |
Elsevier Ltd. |
en |
dc.relation.ispartofseries |
Trends in Pharmacological Sciences |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: http://www.sherpa.ac.uk/romeo/issn/0165-6147/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.source.uri |
http://dx.doi.org/10.1016/j.tips.2010.06.006 |
en |
dc.title |
Regulation of signal transduction by calcitonin gene-related peptide receptors |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.tips.2010.06.006 |
en |
pubs.issue |
10 |
en |
pubs.begin-page |
476 |
en |
pubs.volume |
31 |
en |
dc.rights.holder |
Copyright: Elsevier Ltd. |
en |
pubs.end-page |
483 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.elements-id |
159894 |
en |
pubs.org-id |
Faculty of Science |
en |
pubs.org-id |
Biological Sciences |
en |
pubs.org-id |
Science Resrch Insts & Centres |
en |
pubs.org-id |
Maurice Wilkins Centre |
en |