Autocrine human growth hormone promotes tumour angiogenesis in mammary carcinoma

Show simple item record Brunet-Dunand, Severine en Vouyovitch, C en Araneda, S en Pandey, Vijay en Vidal, Laurent en Print, Cristin en Mertani, HC en Lobie, Peter en Perry, Johanna en 2012-03-12T21:30:42Z en 2009 en
dc.identifier.citation Endocrinology 150(3):1341-1352 Mar 2009 en
dc.identifier.issn 0013-7227 en
dc.identifier.uri en
dc.description.abstract Accumulating literature implicates pathological angiogenesis and lymphangiogenesis as playing key roles in tumour progression. Autocrine human growth hormone (hGH) is a wild-type orthotopically expressed oncogene for the human mammary epithelial cell. Herein we demonstrate that autocrine hGH expression in the human mammary carcinoma cell line, MCF-7, stimulated the survival, proliferation, migration and invasion of a human microvascular endothelial cell line (HMEC-1). Autocrine/paracrine hGH secreted from mammary carcinoma cells also promoted HMEC-1 in vitro tube formation as a consequence of increased VEGF-A expression. Semi-quantitative RT-PCR analysis demonstrated that HMEC-1 cells express both hGH and the hGH receptor (hGHR). Functional antagonism of HMEC-1-derived hGH reduced HMEC-1 survival, proliferation, migration/invasion and tube formation in vitro. Autocrine/paracrine hGH secreted by mammary carcinoma cells increased tumour blood and lymphatic microvessel density in a xenograft model of human mammary carcinoma. Autocrine hGH is therefore a potential master regulator of tumour neovascularisation, coordinating two critical processes in mammary neoplastic progression, angiogenesis and lymphangiogenesis. Consideration of hGH antagonism to inhibit angiogenic processes in mammary carcinoma is therefore warranted. en
dc.publisher The Endocrine Society en
dc.relation.ispartofseries Endocrinology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Autocrine human growth hormone promotes tumour angiogenesis in mammary carcinoma en
dc.type Journal Article en
dc.identifier.doi 10.1210/en.2008-0608 en
pubs.issue 3 en
pubs.begin-page 1341 en
pubs.volume 150 en
dc.rights.holder Copyright: The Endocrine Society en
dc.identifier.pmid 18974274 en
pubs.end-page 1352 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 81373 en Liggins Institute en Medical and Health Sciences en Medical Sciences en Molecular Medicine en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1945-7170 en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 18974274 en

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