dc.contributor.author |
Ward, Marie-Louise |
en |
dc.contributor.author |
Allen, DG |
en |
dc.contributor.editor |
Kamkin, Andre |
en |
dc.contributor.editor |
Kiseleva, Irina |
en |
dc.date.accessioned |
2012-03-07T19:23:07Z |
en |
dc.date.accessioned |
2012-03-12T21:42:46Z |
en |
dc.date.issued |
2009 |
en |
dc.identifier.citation |
In Mechanosensitivity in Cells and Tissues; Mechanosensitivity of the Heart. Editors: Kamkin A, Kiseleva I. 1: 141-167. Springer, United States 2009 |
en |
dc.identifier.isbn |
9789048128495 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/14036 |
en |
dc.description.abstract |
Stretch-activated ion channels are widely expressed in most cell types and play an important role in a variety of normal cell functions, including volume regulation and length detection. In the heart, transduction of mechanical energy into cellular responses is an essential component of cardiac function. The heart is passively stretched, and actively shortens in every cardiac cycle; in addition, longer-term changes in volume occur during exercise, and in diseases such as heart failure. In this article, we discuss the importance of stretch-activated ion channels as mechano-transducers in the heart, with emphasis on their contribution to the regulation of contractile performance. As well, the role of stretch-activated channels in modifying the electrical activity of the heart is also discussed. |
en |
dc.publisher |
Springer |
en |
dc.relation.ispartof |
Mechanosensitivity in Cells and Tissues; Mechanosensitivity of the Heart |
en |
dc.relation.replaces |
http://hdl.handle.net/2292/13272 |
en |
dc.relation.replaces |
2292/13272 |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Stretch-activated channels in the heart: contribution to cardiac performance |
en |
dc.type |
Book Item |
en |
pubs.begin-page |
141 |
en |
dc.rights.holder |
Copyright: Springer |
en |
pubs.author-url |
http://www.springerlink.com/content/j6p562n7102048u4/fulltext.pdf |
en |
pubs.edition |
1 |
en |
pubs.end-page |
167 |
en |
pubs.place-of-publication |
United States |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.elements-id |
79775 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Physiology Division |
en |
pubs.number |
6 |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |