Different preparations of intravenous immunoglobulin vary in their efficacy to neutralize streptococcal superantigens - implications for treatment of streptococcal toxic shock syndrome.

Schrage, B; Duan, Guowen; Yang, Lily; Fraser, John; Proft, Thomas

dc.contributor.author	Schrage, B	en
dc.contributor.author	Duan, Guowen	en
dc.contributor.author	Yang, Lily	en
dc.contributor.author	Fraser, John	en
dc.contributor.author	Proft, Thomas	en
dc.date.accessioned	2012-03-13T19:03:42Z	en
dc.date.issued	2006	en
dc.identifier.citation	Clin Infect Dis 43(6):743-746 15 Sep 2006	en
dc.identifier.issn	1058-4838	en
dc.identifier.uri	http://hdl.handle.net/2292/14166	en
dc.description.abstract	Eight different batches of intravenous immunoglobulin from 3 different manufacturers were tested for neutralizing activities against all currently known streptococcal superantigens. Statistically significant variation among different intravenous immunoglobulin preparations (P < .0001) and between individual streptococcal superantigens (P < .0001) was observed. These results might be helpful for optimizing the type and dose of intravenous immunoglobulin used in adjunctive therapy for severe invasive streptococcal disease.	en
dc.publisher	Oxford University Press	en
dc.relation.ispartofseries	Clinical Infectious Diseases	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1058-4838/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.title	Different preparations of intravenous immunoglobulin vary in their efficacy to neutralize streptococcal superantigens - implications for treatment of streptococcal toxic shock syndrome.	en
dc.type	Journal Article	en
dc.identifier.doi	10.1086/507037	en
pubs.issue	6	en
pubs.begin-page	743	en
pubs.volume	43	en
dc.rights.holder	Copyright: Oxford University Press	en
dc.identifier.pmid	16912949	en
pubs.end-page	746	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	65836	en
pubs.org-id	Medical and Health Sciences	en
pubs.org-id	Medical Sciences	en
pubs.org-id	Molecular Medicine	en
pubs.org-id	Science	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
pubs.record-created-at-source-date	2010-09-01	en
pubs.dimensions-id	16912949	en