A splice variant of the TATA-box binding protein encoding the polyglutamine-containing N-terminal domain that accumulates in Alzheimer's diease

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dc.contributor.author Reid, Susanne en
dc.contributor.author Whittaker, David en
dc.contributor.author Greenwood, Denise en
dc.contributor.author Snell, Russell en
dc.date.accessioned 2012-03-14T00:07:26Z en
dc.date.issued 2009 en
dc.identifier.citation BRAIN RESEARCH 1268:190-199 01 May 2009 en
dc.identifier.issn 0006-8993 en
dc.identifier.uri http://hdl.handle.net/2292/14280 en
dc.description.abstract Previously we have reported the accumulation of an N-terminal fragment of the TATA-box binding protein (TBP) in Alzheimer's disease brain tissue and here we report the identification of a naturally occurring TBP splice variant as a likely mechanism for its production. The splice variant described here encodes the polyglutamine-containing N-terminal domain of this key transcription factor. We demonstrate the expression of the splice variant mRNA in a variety of human tissues and that the resulting protein forms inclusions in cell culture transfection studies. The unusual properties of the variant protein suggest that it may be functionally relevant in late onset neurodegenerative diseases. en
dc.publisher Elsevier Inc en
dc.relation.ispartofseries Brain Research en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0006-8993/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title A splice variant of the TATA-box binding protein encoding the polyglutamine-containing N-terminal domain that accumulates in Alzheimer's diease en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.brainres.2009.03.00 en
pubs.begin-page 190 en
pubs.volume 1268 en
dc.rights.holder Copyright: Elsevier Inc en
dc.identifier.pmid 19285969 en
pubs.end-page 199 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 91700 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Faculty Administration FMHS en
pubs.org-id FMHS Research Support en
pubs.org-id Science en
pubs.org-id Biological Sciences en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 19285969 en


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