Cytosine-gated hole creation and transfer in DNA in aqueous solution

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dc.contributor.author Anderson, Robert en
dc.contributor.author Shinde, Sujata en
dc.contributor.author Maroz, Andrej en
dc.date.accessioned 2012-03-15T02:16:06Z en
dc.date.issued 2006 en
dc.identifier.citation J Am Chem Soc 128(50):15966-15967 20 Dec 2006 en
dc.identifier.issn 0002-7863 en
dc.identifier.uri http://hdl.handle.net/2292/14430 en
dc.description.abstract The underlying mechanism of charge generation and transfer in DNA is of fundamental importance to the understanding of freeradical-induced damage 1,2 and the development of both molecular electronic and biosensor devices. 3 Oxidatively generated damage to DNA by radical attack and absorption of ionizing radiation leads to selective strand cleavage at guanine (and multi-guanine) sites through the migration of electron-loss centers (holes) in DNA. 4 It is known from measurements of ionization potentials, IP, that the purine bases in isolation are more easily oxidized than the pyrimidine bases, 5 and theoretical gas-phase calculations give the order of ease of oxidation as guanine,G > adenine,A . cytosine,C > thymine,T. 6 This has been borne out in aqueous solution where the measured value for the one-electron reduction potential of the guanyl radical (for guanosine), E(G¥ , H+ /G), is 1.29 V compared to the radicals of adenosine (1.42 V), 2′-deoxycytidine (ca. 1.6 V), and thymidine (ca. 1.7 V). en
dc.publisher American Chemical Society en
dc.relation.ispartofseries Journal of the American Chemical Society en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0002-7863/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Cytosine-gated hole creation and transfer in DNA in aqueous solution en
dc.type Journal Article en
dc.identifier.doi 10.1021/ja0658416 en
pubs.begin-page 15966 en
pubs.volume 128 en
dc.rights.holder Copyright: American Chemical Society en
dc.identifier.pmid 17165712 en
pubs.end-page 15967 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 68200 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Auckland Cancer Research en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 17165712 en


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