Optimisation of bioluminescent reporters for use with mycobacteria.

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dc.contributor.author Andreu, N en
dc.contributor.author Zelmer, A en
dc.contributor.author Fletcher, T en
dc.contributor.author Elkington, PT en
dc.contributor.author Ward, TH en
dc.contributor.author Ripoll, J en
dc.contributor.author Parish, T en
dc.contributor.author Bancroft, GJ en
dc.contributor.author Schaible, U en
dc.contributor.author Robertson, BD en
dc.contributor.author Wiles, Siouxsie en
dc.coverage.spatial United States en
dc.date.accessioned 2012-03-15T19:51:10Z en
dc.date.issued 2010 en
dc.identifier.citation PLoS One 5(5):e10777 2010 en
dc.identifier.issn 1932-6203 en
dc.identifier.uri http://hdl.handle.net/2292/14452 en
dc.description.abstract Mycobacterium tuberculosis, the causative agent of tuberculosis, still represents a major public health threat in many countries. Bioluminescence, the production of light by luciferase-catalyzed reactions, is a versatile reporter technology with multiple applications both in vitro and in vivo. In vivo bioluminescence imaging (BLI) represents one of its most outstanding uses by allowing the non-invasive localization of luciferase-expressing cells within a live animal. Despite the extensive use of luminescent reporters in mycobacteria, the resultant luminescent strains have not been fully applied to BLI. en
dc.language eng en
dc.publisher Public Library of Science en
dc.relation.ispartofseries PLOS ONE en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: http://www.sherpa.ac.uk/romeo/issn/1932-6203/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri http://creativecommons.org/licenses/by/2.5/ en
dc.subject Animals en
dc.subject Codon en
dc.subject Gene Expression en
dc.subject Genes, Reporter en
dc.subject Genetic Vectors en
dc.subject Imaging, Three-Dimensional en
dc.subject Kinetics en
dc.subject Luciferases en
dc.subject Luminescent Proteins en
dc.subject Mice en
dc.subject Mycobacterium smegmatis en
dc.subject Whole Body Imaging en
dc.title Optimisation of bioluminescent reporters for use with mycobacteria. en
dc.type Journal Article en
dc.identifier.doi 10.1371/journal.pone.0010777 en
pubs.issue 5 en
pubs.begin-page e10777 en
pubs.volume 5 en
dc.rights.holder Copyright: Public Library of Science en
dc.identifier.pmid 20520722 en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 119499 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Molecular Medicine en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1932-6203 en
pubs.record-created-at-source-date 2012-02-14 en
pubs.dimensions-id 20520722 en

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