dc.contributor.author |
Andreu, N |
en |
dc.contributor.author |
Zelmer, A |
en |
dc.contributor.author |
Fletcher, T |
en |
dc.contributor.author |
Elkington, PT |
en |
dc.contributor.author |
Ward, TH |
en |
dc.contributor.author |
Ripoll, J |
en |
dc.contributor.author |
Parish, T |
en |
dc.contributor.author |
Bancroft, GJ |
en |
dc.contributor.author |
Schaible, U |
en |
dc.contributor.author |
Robertson, BD |
en |
dc.contributor.author |
Wiles, Siouxsie |
en |
dc.coverage.spatial |
United States |
en |
dc.date.accessioned |
2012-03-15T19:51:10Z |
en |
dc.date.issued |
2010 |
en |
dc.identifier.citation |
PLoS One 5(5):e10777 2010 |
en |
dc.identifier.issn |
1932-6203 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/14452 |
en |
dc.description.abstract |
Mycobacterium tuberculosis, the causative agent of tuberculosis, still represents a major public health threat in many countries. Bioluminescence, the production of light by luciferase-catalyzed reactions, is a versatile reporter technology with multiple applications both in vitro and in vivo. In vivo bioluminescence imaging (BLI) represents one of its most outstanding uses by allowing the non-invasive localization of luciferase-expressing cells within a live animal. Despite the extensive use of luminescent reporters in mycobacteria, the resultant luminescent strains have not been fully applied to BLI. |
en |
dc.language |
eng |
en |
dc.publisher |
Public Library of Science |
en |
dc.relation.ispartofseries |
PLOS ONE |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: http://www.sherpa.ac.uk/romeo/issn/1932-6203/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
http://creativecommons.org/licenses/by/2.5/ |
en |
dc.subject |
Animals |
en |
dc.subject |
Codon |
en |
dc.subject |
Gene Expression |
en |
dc.subject |
Genes, Reporter |
en |
dc.subject |
Genetic Vectors |
en |
dc.subject |
Imaging, Three-Dimensional |
en |
dc.subject |
Kinetics |
en |
dc.subject |
Luciferases |
en |
dc.subject |
Luminescent Proteins |
en |
dc.subject |
Mice |
en |
dc.subject |
Mycobacterium smegmatis |
en |
dc.subject |
Whole Body Imaging |
en |
dc.title |
Optimisation of bioluminescent reporters for use with mycobacteria. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1371/journal.pone.0010777 |
en |
pubs.issue |
5 |
en |
pubs.begin-page |
e10777 |
en |
pubs.volume |
5 |
en |
dc.rights.holder |
Copyright: Public Library of Science |
en |
dc.identifier.pmid |
20520722 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
119499 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Molecular Medicine |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1932-6203 |
en |
pubs.record-created-at-source-date |
2012-02-14 |
en |
pubs.dimensions-id |
20520722 |
en |