Persistent comorbid symptoms of depression and anxiety predict mortality in heart disease

Show simple item record Doering, LV en Moser, DK en Riegel, B en McKinley, S en Davidson, P en Baker, Heather en Meischke, H en Dracup, K en 2012-03-15T22:36:40Z en 2010 en
dc.identifier.citation International Journal of Cardiology 145:188-192 2010 en
dc.identifier.issn 0167-5273 en
dc.identifier.uri en
dc.description.abstract Background Incident anxiety and depression are associated separately with cardiac events and mortality in patients after acute coronary syndromes, but the influence of persistent comorbid depression and anxiety on mortality remains unknown. The purpose of this study was to determine the prevalence of comorbid persistent depressive and anxious symptoms in individuals with ischemic heart disease and to evaluate effects on mortality. Methods Prospective, longitudinal cohort design in the context of a randomized trial to decrease patient delay in seeking treatment for ischemic heart symptoms (PROMOTION trial) was used, with twelve-month follow-up of 2325 individuals with stable ischemic heart disease. Participants were assessed on enrollment and at 3 months using the Multiple Adjective Affect Checklist and the Brief Symptom Inventory for depressive and anxious symptoms, respectively. Results At 3 months, 608 individuals (61.7%) reported persistent symptoms of depression, anxiety, or both. Three hundred seventy-nine (42.5%) and 1056 (45.4%) had persistent anxious and depressive symptoms, respectively. Those with persistent, comorbid symptoms had higher mortality compared to others (p = .029). The combined presence of anxious and depressive symptoms contributed significantly to mortality when compared to symptom-free participants (OR 2.35, 95% CI 1.23–4.47, p = .010). The presence of persistent depressive symptoms only and persistent anxious symptoms only were not associated with death, when other demographic and clinical variables were considered. Conclusions Persistent symptoms of anxiety and depression increased substantially the risk of death in patients with ischemic heart disease. Future research into shared and unique pathways and treatments is needed. en
dc.publisher Elsevier Ireland Ltd en
dc.relation.ispartofseries International Journal of Cardiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Persistent comorbid symptoms of depression and anxiety predict mortality in heart disease en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.ijcard.2009.05.025 en
pubs.begin-page 188 en
pubs.volume 145 en
dc.rights.holder Copyright: Elsevier Ireland Ltd en
pubs.end-page 192 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 311925 en Medical and Health Sciences en Nursing en
pubs.record-created-at-source-date 2012-03-05 en

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