Are biofilms associated with an inflammatory response in chronic rhinosinusitis?

Show simple item record Wood, Andrew en Fraser, John en Swift, Simon en Amirapu, Satya en Douglas, Richard en 2012-03-21T00:14:17Z en 2011 en
dc.identifier.citation Int Forum Allergy Rhinol 1(5):335-339 2011 en
dc.identifier.issn 2042-6976 en
dc.identifier.uri en
dc.description.abstract Background: Bacterial biofilms have been identified on the sinonasal mucosa of patients with chronic rhinosinusitis (CRS) but also on control samples. Their role in the disease pathogenesis is unproven. The objective of this study was to further evaluate the role of biofilms in CRS by assessing whether they are associated with an inflammatory response. Methods: Mucosal samples were collected from 18 patients with CRS and 7 normal subjects. Bacteria on the mucosal surface were identified by Gram stain. Immune cells were identified by Giemsa stain and immunohistochemistry (IHC). The number of local immune cells was recorded beneath areas of the mucosal surface both colonized with and free from bacteria. Results: In CRS patients, biofilms that were directly opposed to a disrupted epithelial layer were associated with more T lymphocytes (p = 0.01), and more macrophages (p = 0.003) than areas of mucosa without bacteria present. Biofilms associated with but not directly opposed to the epithelium were not associated with raised numbers of immune cells. Conclusion: Not all surface bacterial colonies are associated with a particular inflammatory response in CRS. Biofilms adherent to a disrupted epithelial layer are associated with higher numbers of immune cells and therefore appear to have a role in the pathogenesis of CRS. en
dc.publisher American Academy of Otolaryngologic Allergy en
dc.relation.ispartofseries International Forum of Allergy & Rhinology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Are biofilms associated with an inflammatory response in chronic rhinosinusitis? en
dc.type Journal Article en
dc.identifier.doi 10.1002/alr.20060 en
pubs.issue 5 en
pubs.begin-page 335 en
pubs.volume 1 en
dc.rights.holder Copyright: American Academy of Otolaryngologic Allergy en
dc.identifier.pmid 22287462 en
pubs.end-page 339 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 228132 en Medical and Health Sciences en Medical Sciences en Molecular Medicine en School of Medicine en Surgery Department en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2011-09-30 en
pubs.dimensions-id 22287462 en

Files in this item

There are no files associated with this item.

Find Full text

This item appears in the following Collection(s)

Show simple item record


Search ResearchSpace