dc.contributor.author |
Mathur, S |
en |
dc.contributor.author |
Plank, Lindsay |
en |
dc.contributor.author |
McCall, JL |
en |
dc.contributor.author |
Shapkov, P |
en |
dc.contributor.author |
McIlroy, K |
en |
dc.contributor.author |
Gillanders, LK |
en |
dc.contributor.author |
Merrie, Arend |
en |
dc.contributor.author |
Torrie, JJ |
en |
dc.contributor.author |
Pugh, F |
en |
dc.contributor.author |
Koea, JB |
en |
dc.contributor.author |
Bissett, Ian |
en |
dc.contributor.author |
Parry, Bryan |
en |
dc.date.accessioned |
2012-03-21T00:14:42Z |
en |
dc.date.issued |
2010 |
en |
dc.identifier.citation |
Br J Surg 97(4):485-494 Apr 2010 |
en |
dc.identifier.issn |
1365-2168 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/14745 |
en |
dc.description.abstract |
BACKGROUND: Major surgery is associated with postoperative insulin resistance which is attenuated by preoperative carbohydrate (CHO) treatment. The effect of this treatment on clinical outcome after major abdominal surgery has not been assessed in a double-blind randomized trial. METHODS: Patients undergoing elective colorectal surgery or liver resection were randomized to oral CHO or placebo drinks to be taken on the evening before surgery and 2 h before induction of anaesthesia. Primary outcomes were postoperative length of hospital stay and fatigue measured by visual analogue scale. RESULTS: Sixty-nine and 73 patients were evaluated in the CHO and placebo groups respectively. The groups were well matched with respect to surgical procedure, epidural analgesia, laparoscopic procedures, fasting period before induction and duration of surgery. Postoperative changes in fatigue score from baseline did not differ between the groups. Median (range) hospital stay was 7 (2-35) days in the CHO group and 8 (2-92) days in the placebo group (P = 0.344). For patients not receiving epidural blockade or laparoscopic surgery (20 CHO, 19 placebo), values were 7 (3-11) and 9 (2-48) days respectively (P = 0.054). CONCLUSION: Preoperative CHO treatment did not improve postoperative fatigue or length of hospital stay after major abdominal surgery. A benefit is not ruled out when epidural blockade or laparoscopic procedures are not used. Registration number: ACTRN012605000456651 (http://www.anzctr.org.au). Copyright (c) 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. |
en |
dc.publisher |
British Journal of Surgery Society |
en |
dc.relation.ispartofseries |
British Journal of Surgery |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0007-1323/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Administration, Oral Adult Aged Aged, 80 and over Blood Glucose/me [Metabolism] C-Reactive Protein/me [Metabolism] *Carbohydrates/ad [Administration & Dosage] Colonic Diseases/me [Metabolism] *Colonic Diseases/su [Surgery] Double-Blind Method Fatigue/et [Etiology] Female Hand Strength/ph [Physiology] Humans Hydrocortisone/me [Metabolism] Insulin/me [Metabolism] Insulin Resistance/ph [Physiology] Laparoscopy Length of Stay Liver Diseases/me [Metabolism] *Liver Diseases/su [Surgery] Male Middle Aged Muscle, Skeletal/ah [Anatomy & Histology] Postoperative Complications/me [Metabolism] Postoperative Complications/pc [Prevention & Control] Preoperative Care/mt [Methods] Rectal Diseases/me [Metabolism] *Rectal Diseases/su [Surgery] Treatment Outcome 0 (Blood Glucose) 0 (Carbohydrates) 11061-68-0 (Insulin) 50-23-7 (Hydrocortisone) 9007-41-4 (C-Reactive Protein) |
en |
dc.title |
Randomized controlled trial of preoperative oral carbohydrate treatment in major abdominal surgery |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1002/bjs.7026 |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
485 |
en |
pubs.volume |
97 |
en |
dc.rights.holder |
Copyright: British Journal of Surgery Society |
en |
dc.identifier.pmid |
20205227 |
en |
pubs.author-url |
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=20205227 |
en |
pubs.end-page |
494 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
119217 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Surgery Department |
en |
pubs.record-created-at-source-date |
2010-12-17 |
en |
pubs.dimensions-id |
20205227 |
en |