GPCR modulation by RAMPs

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Show simple item record Hay, Deborah en Poyner, DR en Sexton, PM en 2012-03-21T00:18:46Z en 2006 en
dc.identifier.citation Pharmacology & Therapeutics 109(1-2):173-197 2006 en
dc.identifier.issn 0163-7258 en
dc.identifier.uri en
dc.description.abstract Our conceptual understanding of the molecular architecture of G-protein coupled receptors (GPCRs) has transformed over the last decade. Once considered as largely independent functional units (aside from their interaction with the G-protein itself), it is now clear that a single GPCR is but part of a multifaceted signaling complex, each component providing an additional layer of sophistication. Receptor activity-modifying proteins (RAMPs) provide a notable example of proteins that interact with GPCRs to modify their function. They act as pharmacological switches, modifying GPCR pharmacology for a particular subset of receptors. However, there is accumulating evidence that these ubiquitous proteins have a broader role, regulating signaling and receptor trafficking. This article aims to provide the reader with a comprehensive appraisal of RAMP literature and perhaps some insight into the impact that their discovery has had on those who study GPCRs. en
dc.publisher Elsevier Inc en
dc.relation.ispartofseries Pharmacology & Therapeutics en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title GPCR modulation by RAMPs en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.pharmthera.2005.06.015 en
pubs.issue 1-2 en
pubs.begin-page 173 en
pubs.volume 109 en
dc.rights.holder Copyright: Elsevier Inc. en
dc.identifier.pmid 16111761 en
pubs.end-page 197 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 49623 en Science en Biological Sciences en Science Research en Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 16111761 en

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